tetano
Editor, Senior Moderator
Nat Immunol. 2020 Jan 13. doi: 10.1038/s41590-019-0568-x. [Epub ahead of print] [h=1]Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.[/h]
Aegerter H[SUP]1[/SUP], Kulikauskaite J[SUP]1[/SUP], Crotta S[SUP]1[/SUP], Patel H[SUP]2[/SUP], Kelly G[SUP]2[/SUP], Hessel EM[SUP]3[/SUP], Mack M[SUP]4[/SUP], Beinke S[SUP]3[/SUP], Wack A[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
PMID: 31932810 DOI: 10.1038/s41590-019-0568-x
Aegerter H[SUP]1[/SUP], Kulikauskaite J[SUP]1[/SUP], Crotta S[SUP]1[/SUP], Patel H[SUP]2[/SUP], Kelly G[SUP]2[/SUP], Hessel EM[SUP]3[/SUP], Mack M[SUP]4[/SUP], Beinke S[SUP]3[/SUP], Wack A[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
PMID: 31932810 DOI: 10.1038/s41590-019-0568-x