tetano
Editor, Senior Moderator
Nat Immunol
. 2023 Jan 30.
doi: 10.1038/s41590-022-01410-z. Online ahead of print.
The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19
Stefano Suzzi[SUP] #[/SUP][SUP] 1 [/SUP], Afroditi Tsitsou-Kampeli[SUP] #[/SUP][SUP] 1 [/SUP], Michal Schwartz[SUP] 2 [/SUP]
Affiliations
Abstract
The type I interferon (IFN) response is the body's typical immune defense against viruses. Previous studies linked high expression of genes encoding type I IFNs in the brain's choroid plexus to cognitive decline under virus-free conditions in aging and neurodegeneration. Multiple reports have documented persisting cognitive symptoms following recovery from COVID-19. Cumulative evidence shows that the choroid plexus is one of the brain regions most vulnerable to infection with the coronavirus SARS-CoV-2, and manifests increased expression of genes encoding type I IFNs even in the absence of viral traces within the brain. In this Perspective, we propose that the type I IFN defensive immune response to SARS-CoV-2 infection in the choroid plexus poses a risk to cognitive function if not resolved in a timely manner.
. 2023 Jan 30.
doi: 10.1038/s41590-022-01410-z. Online ahead of print.
The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19
Stefano Suzzi[SUP] #[/SUP][SUP] 1 [/SUP], Afroditi Tsitsou-Kampeli[SUP] #[/SUP][SUP] 1 [/SUP], Michal Schwartz[SUP] 2 [/SUP]
Affiliations
- PMID: 36717725
- DOI: 10.1038/s41590-022-01410-z
Abstract
The type I interferon (IFN) response is the body's typical immune defense against viruses. Previous studies linked high expression of genes encoding type I IFNs in the brain's choroid plexus to cognitive decline under virus-free conditions in aging and neurodegeneration. Multiple reports have documented persisting cognitive symptoms following recovery from COVID-19. Cumulative evidence shows that the choroid plexus is one of the brain regions most vulnerable to infection with the coronavirus SARS-CoV-2, and manifests increased expression of genes encoding type I IFNs even in the absence of viral traces within the brain. In this Perspective, we propose that the type I IFN defensive immune response to SARS-CoV-2 infection in the choroid plexus poses a risk to cognitive function if not resolved in a timely manner.