tetano
Editor, Senior Moderator
Nat Methods
. 2022 Apr 8.
doi: 10.1038/s41592-022-01453-y. Online ahead of print.
Human organoid models to study SARS-CoV-2 infection
Yuling Han[SUP] #[/SUP][SUP] 1 [/SUP], Liuliu Yang[SUP] #[/SUP][SUP] 1 [/SUP], Lauretta A Lacko[SUP] 1 [/SUP], Shuibing Chen[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS-CoV-2 not only infects the respiratory tract, but also causes damage to many organs. Organoids, which can self-renew and recapitulate the various physiology of different organs, serve as powerful platforms to model COVID-19. In this Perspective, we overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development. We summarize the technologies used in organoid-based COVID-19 research, discuss the remaining challenges and provide future perspectives in the application of organoid models to study SARS-CoV-2 and future emerging viruses.
. 2022 Apr 8.
doi: 10.1038/s41592-022-01453-y. Online ahead of print.
Human organoid models to study SARS-CoV-2 infection
Yuling Han[SUP] #[/SUP][SUP] 1 [/SUP], Liuliu Yang[SUP] #[/SUP][SUP] 1 [/SUP], Lauretta A Lacko[SUP] 1 [/SUP], Shuibing Chen[SUP] 2 [/SUP]
Affiliations
- PMID: 35396481
- DOI: 10.1038/s41592-022-01453-y
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS-CoV-2 not only infects the respiratory tract, but also causes damage to many organs. Organoids, which can self-renew and recapitulate the various physiology of different organs, serve as powerful platforms to model COVID-19. In this Perspective, we overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development. We summarize the technologies used in organoid-based COVID-19 research, discuss the remaining challenges and provide future perspectives in the application of organoid models to study SARS-CoV-2 and future emerging viruses.