tetano
Editor, Senior Moderator
Nat Microbiol
. 2025 Mar 17.
doi: 10.1038/s41564-025-01961-5. Online ahead of print. Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow's milk
Jeremy C Jones[SUP] 1 [/SUP], Konstantin Andreev[SUP] 1 [/SUP], Thomas P Fabrizio[SUP] 1 [/SUP], Andrew S Bowman[SUP] 2 [/SUP], Elena A Govorkova[SUP] 1 [/SUP], Richard J Webby[SUP] 3 [/SUP]
Affiliations
Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans due to A(H5N1) disease severity. Here, in mice, we demonstrate that US FDA-approved baloxavir treatment mediates improved disease outcomes (survival and viral dissemination) over oseltamivir after lethal intranasal and ocular challenge with A(H5N1)-contaminated cow milk.
. 2025 Mar 17.
doi: 10.1038/s41564-025-01961-5. Online ahead of print. Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow's milk
Jeremy C Jones[SUP] 1 [/SUP], Konstantin Andreev[SUP] 1 [/SUP], Thomas P Fabrizio[SUP] 1 [/SUP], Andrew S Bowman[SUP] 2 [/SUP], Elena A Govorkova[SUP] 1 [/SUP], Richard J Webby[SUP] 3 [/SUP]
Affiliations
- PMID: 40097765
- DOI: 10.1038/s41564-025-01961-5
Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans due to A(H5N1) disease severity. Here, in mice, we demonstrate that US FDA-approved baloxavir treatment mediates improved disease outcomes (survival and viral dissemination) over oseltamivir after lethal intranasal and ocular challenge with A(H5N1)-contaminated cow milk.