tetano
Editor, Senior Moderator
Nat Rev Genet
. 2022 May 2.
doi: 10.1038/s41576-022-00478-5. Online ahead of print.
The human genetic epidemiology of COVID-19
Mari E K Niemi[SUP] 1 [/SUP], Mark J Daly[SUP] 1 2 3 [/SUP], Andrea Ganna[SUP] 4 5 6 [/SUP]
Affiliations
Abstract
Human genetics can inform the biology and epidemiology of coronavirus disease 2019 (COVID-19) by pinpointing causal mechanisms that explain why some individuals become more severely affected by the disease upon infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Large-scale genetic association studies, encompassing both rare and common genetic variants, have used different study designs and multiple disease phenotype definitions to identify several genomic regions associated with COVID-19. Along with a multitude of follow-up studies, these findings have increased our understanding of disease aetiology and provided routes for management of COVID-19. Important emergent opportunities include the clinical translatability of genetic risk prediction, the repurposing of existing drugs, exploration of variable host effects of different viral strains, study of inter-individual variability in vaccination response and understanding the long-term consequences of SARS-CoV-2 infection. Beyond the current pandemic, these transferrable opportunities are likely to affect the study of many infectious diseases.
. 2022 May 2.
doi: 10.1038/s41576-022-00478-5. Online ahead of print.
The human genetic epidemiology of COVID-19
Mari E K Niemi[SUP] 1 [/SUP], Mark J Daly[SUP] 1 2 3 [/SUP], Andrea Ganna[SUP] 4 5 6 [/SUP]
Affiliations
- PMID: 35501396
- DOI: 10.1038/s41576-022-00478-5
Abstract
Human genetics can inform the biology and epidemiology of coronavirus disease 2019 (COVID-19) by pinpointing causal mechanisms that explain why some individuals become more severely affected by the disease upon infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Large-scale genetic association studies, encompassing both rare and common genetic variants, have used different study designs and multiple disease phenotype definitions to identify several genomic regions associated with COVID-19. Along with a multitude of follow-up studies, these findings have increased our understanding of disease aetiology and provided routes for management of COVID-19. Important emergent opportunities include the clinical translatability of genetic risk prediction, the repurposing of existing drugs, exploration of variable host effects of different viral strains, study of inter-individual variability in vaccination response and understanding the long-term consequences of SARS-CoV-2 infection. Beyond the current pandemic, these transferrable opportunities are likely to affect the study of many infectious diseases.