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The full picture of post-COVID-19 autoimmune diseases and their prevalence is lacking despite numerous case reports and small series. Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases.
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A similar study by Tesch et. al.[SUP]3[/SUP], which has not yet been peer-reviewed, evaluated a cohort of 640,701 vaccination-naive individuals with PCR-confirmed COVID-19 during 2020 for the risk of autoimmune conditions. The researchers identified a 42.6% higher likelihood of acquiring an autoimmune condition 3–15 months after infection compared with a non-COVID-19 cohort of 1,560,357 individuals matched for age, sex and whether they had a preexisting autoimmune disease[SUP]3[/SUP]. The highest incidence rate ratios were found for vasculitis conditions, which are relatively rare autoimmune diseases. The results also emphasize that among individuals with preexisting autoimmune conditions, COVID-19 increased the risk of developing another autoimmune disease by 23%. Owing to the inherent nature of their design (retrospective cohort), these two studies do not prove a causal link between SARS-CoV-2 and the development of autoimmune diseases; however, based on the temporal association with a history of COVID-19, they provide compelling and reliable evidence that SARS-CoV-2 infection is linked to a substantially increased risk of developing diverse new-onset autoimmune diseases after the acute phase of SARS-CoV-2 infection.
