Nature: Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

[sharon sanders]

• Letter
• Published: 18 June 2020

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

• Quan-Xin Long,
• Xiao-Jun Tang,
• Qiu-Lin Shi,
• Qin Li,
• Hai-Jun Deng,
• Jun Yuan,
• Jie-Li Hu,
• Wei Xu,
• Yong Zhang,
• Fa-Jin Lv,
• Kun Su,
• Fan Zhang,
• Jiang Gong,
• Bo Wu,
• Xia-Mao Liu,
• Jin-Jing Li,
• Jing-Fu Qiu,
• Juan Chen &
• Ai-Long Huang

Nature Medicine (2020)Cite this article

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Abstract


The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People’s Hospital for centralized isolation in accordance with policy[SUP]1[/SUP]. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15–26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6–10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8–38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients.

Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.

https://www.nature.com/articles/s41591-020-0965-6

 

[bertrand789]

Au secours, c'est propre, mais juste digne du lancet, de mon point de vue. Il me semble urgent que ceux qui ont travaill? sur le concept d'animal porteur sain, ?claire un peu ce dossier ...


Cela existe des v?t?rinaires en Chine ?