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Editor, Senior Moderator
Nature Communications | Article
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zhen Zou,
Yiwu Yan,
Yuelong Shu,
Rongbao Gao,
Yang Sun,
Xiao Li,
Xiangwu Ju,
Zhu Liang,
Qiang Liu,
Yan Zhao,
Feng Guo,
Tian Bai,
Zongsheng Han,
Jindong Zhu,
Huandi Zhou,
Fengming Huang,
Chang Li,
Huijun Lu,
Ning Li,
Dangsheng Li
et al.
Nature Communications
5,
Article number:
3594
doi:10.1038/ncomms4594
Abstract
The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection, at least in some patients. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. Genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice, confirming a role of ACE2 in H5N1-induced lung pathologies. Administration of recombinant human ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice. Our data link H5N1 virus-induced acute lung failure to ACE2 and provide a potential treatment strategy to address future flu pandemics.
http://www.nature.com/ncomms/2014/140506/ncomms4594/full/ncomms4594.html
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zhen Zou,
Yiwu Yan,
Yuelong Shu,
Rongbao Gao,
Yang Sun,
Xiao Li,
Xiangwu Ju,
Zhu Liang,
Qiang Liu,
Yan Zhao,
Feng Guo,
Tian Bai,
Zongsheng Han,
Jindong Zhu,
Huandi Zhou,
Fengming Huang,
Chang Li,
Huijun Lu,
Ning Li,
Dangsheng Li
et al.
Nature Communications
5,
Article number:
3594
doi:10.1038/ncomms4594
Abstract
The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly increased serum levels of angiotensin II. High serum levels of angiotensin II appear to be linked to the severity and lethality of infection, at least in some patients. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. Genetic inactivation of ACE2 causes severe lung injury in H5N1-challenged mice, confirming a role of ACE2 in H5N1-induced lung pathologies. Administration of recombinant human ACE2 ameliorates avian influenza H5N1 virus-induced lung injury in mice. Our data link H5N1 virus-induced acute lung failure to ACE2 and provide a potential treatment strategy to address future flu pandemics.
http://www.nature.com/ncomms/2014/140506/ncomms4594/full/ncomms4594.html