Emily
Editor, Senior Moderator
https://www.nature.com/articles/s41423-021-00772-y
Arora, P., Kempf, A., Nehlmeier, I. et al. Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance. Cell Mol Immunol (2021). https://doi.org/10.1038/s41423-021-00772-y
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Our results reveal no appreciable differences between host cell entry and neutralization sensitivity of the Delta variant and its sublineages, with the notable exception of the Delta Plus variant being resistant to both bamlanivimab and etesevimab, which are used in cocktails for COVID-19 treatment. Although T-cell responses were not analyzed in the present study and confirmation of the data using authentic virus and primary cells is pending, our results suggest that neither the Delta Plus nor the Delta-V variant is associated with an increased threat to convalescent or BNT162b2/Comirnaty vaccinated patients compared to the founder virus. Finally, it is noteworthy that heterologous ChAdOx1 nCov-19/BNT162b2 vaccination might provide particularly robust protection against these viruses [12].
Arora, P., Kempf, A., Nehlmeier, I. et al. Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance. Cell Mol Immunol (2021). https://doi.org/10.1038/s41423-021-00772-y
...
Our results reveal no appreciable differences between host cell entry and neutralization sensitivity of the Delta variant and its sublineages, with the notable exception of the Delta Plus variant being resistant to both bamlanivimab and etesevimab, which are used in cocktails for COVID-19 treatment. Although T-cell responses were not analyzed in the present study and confirmation of the data using authentic virus and primary cells is pending, our results suggest that neither the Delta Plus nor the Delta-V variant is associated with an increased threat to convalescent or BNT162b2/Comirnaty vaccinated patients compared to the founder virus. Finally, it is noteworthy that heterologous ChAdOx1 nCov-19/BNT162b2 vaccination might provide particularly robust protection against these viruses [12].
