Giuseppe
Emeritus
Dissolving polymer microneedle patches for influenza vaccination (Nature Medicine, abstract, edited)
[Source: Nature Medicine, <cite cite="http://www.nature.com/nm/journal/v16/n8/abs/nm.2182.html">Dissolving polymer microneedle patches for influenza vaccination : Nature Medicine : Nature Publishing Group</cite>. Abstract, edited.]
Dissolving polymer microneedle patches for influenza vaccination
* Sean P Sullivan, * Dimitrios G Koutsonanos, * Maria del Pilar Martin, * Jeong Woo Lee, * Vladimir Zarnitsyn, * Seong-O Choi, * Niren Murthy, * Richard W Compans, * Ioanna Skountzou * & Mark R Prausnitz
Journal name: Nature Medicine - Volume: 16, Pages: 915?920 - Year published: (2010)
DOI: doi:10.1038/nm.2182
Received 30 July 2009
Accepted 23 April 2010
Published online 18 July 2010
Abstract
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.
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[Source: Nature Medicine, <cite cite="http://www.nature.com/nm/journal/v16/n8/abs/nm.2182.html">Dissolving polymer microneedle patches for influenza vaccination : Nature Medicine : Nature Publishing Group</cite>. Abstract, edited.]
Dissolving polymer microneedle patches for influenza vaccination
* Sean P Sullivan, * Dimitrios G Koutsonanos, * Maria del Pilar Martin, * Jeong Woo Lee, * Vladimir Zarnitsyn, * Seong-O Choi, * Niren Murthy, * Richard W Compans, * Ioanna Skountzou * & Mark R Prausnitz
Journal name: Nature Medicine - Volume: 16, Pages: 915?920 - Year published: (2010)
DOI: doi:10.1038/nm.2182
Received 30 July 2009
Accepted 23 April 2010
Published online 18 July 2010
Abstract
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.
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