Nature: Epidemiological and Evolutionary Inference of the Transmission Network of the 2014 Highly Pathogenic Avian Influenza H5N2 Outbreak in British

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[h=1]Epidemiological and Evolutionary Inference of the Transmission Network of the 2014 Highly Pathogenic Avian Influenza H5N2 Outbreak in British Columbia, Canada[/h]

• Wanhong Xu[SUP]1[/SUP]
• , Yohannes Berhane[SUP]1[/SUP]
• , Caroline Dub?[SUP]2[/SUP]
• , Binhua Liang[SUP]3, 4[/SUP]
• , John Pasick[SUP]1[/SUP]
• , Gary VanDomselaar[SUP]3, 5[/SUP]
• & Soren Alexandersen[SUP]1, 6[/SUP]

• Scientific Reports 6, Article number: 30858 (2016)
• doi:10.1038/srep30858

The first North American outbreak of highly pathogenic avian influenza (HPAI) involving a virus of Eurasian A/goose/Guangdong/1/1996 (H5N1) lineage began in the Fraser Valley of British Columbia, Canada in late November 2014. A total of 11 commercial and 1 non-commercial (backyard) operations were infected before the outbreak was terminated. Control measures included movement restrictions that were placed on a total of 404 individual premises, 150 of which were located within a 3 km radius of an infected premise(s) (IP). A complete epidemiological investigation revealed that the source of this HPAI H5N2 virus for 4 of the commercial IPs and the single non-commercial IP likely involved indirect contact with wild birds. Three IPs were associated with the movement of birds or service providers and localized/environmental spread was suspected as the source of infection for the remaining 4 IPs. Viral phylogenies, as determined by Bayesian Inference and Maximum Likelihood methods, were used to validate the epidemiologically inferred transmission network. The phylogenetic clustering of concatenated viral genomes and the median-joining phylogenetic network of the viruses supported, for the most part, the transmission network that was inferred by the epidemiologic analysis.

full article

http://www.nature.com/articles/srep30858