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The influenza subtype responsible for most of the US cases so far is H1N1, in a flip from last year, when H3N2 dominated. And sequencing data from these early cases point to an emerging mutation in H1N1 that is causing concern among specialists.
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This year, the H1N1 mutation that is worrying researchers is G155E. Alex Greninger, a virologist at the University of Washington in Seattle, says that his laboratory detected G155E in 13 of 17 H1N1 samples taken from people in whom the genetic sequences were complete enough to identify specific mutations. The samples had come from hospitals and clinics in Seattle over the past few months.
This mutation had already been flagged in an analysis led by Jesse Bloom, a virologist at the Fred Hutchinson Cancer Center in Seattle, which was posted on the preprint server bioRxiv last month, ahead of peer review1.
