tetano
Editor, Senior Moderator
Nature. 2020 May 12. doi: 10.1038/s41586-020-2324-7. [Epub ahead of print]
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
Munster VJ[SUP]1[/SUP], Feldmann F[SUP]2[/SUP], Williamson BN[SUP]1[/SUP], van Doremalen N[SUP]1[/SUP], P?rez-P?rez L[SUP]1[/SUP], Schulz J[SUP]1[/SUP], Meade-White K[SUP]1[/SUP], Okumura A[SUP]1[/SUP], Callison J[SUP]1[/SUP], Brumbaugh B[SUP]3[/SUP], Avanzato VA[SUP]1[/SUP], Rosenke R[SUP]2[/SUP], Hanley PW[SUP]2[/SUP], Saturday G[SUP]2[/SUP], Scott D[SUP]2[/SUP], Fischer ER[SUP]3[/SUP], de Wit E[SUP]4[/SUP].
Author information
Abstract
An outbreak of a novel coronavirus, named SARS-CoV-2, causing respiratory disease and a ~2% case fatality rate started in Wuhan, China in December 2019[SUP]1,2[/SUP]. Following unprecedented global spread[SUP]3[/SUP], the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models, where repeated sampling and tissue collection is possible. Here, we show that SARS-CoV-2 causes respiratory disease in infected rhesus macaques, with disease lasting 8-16 days. Pulmonary infiltrates, a hallmark of human disease, were visible in lung radiographs. High viral loads were detected in swabs from the nose and throat of all animals as well as in bronchoalveolar lavages; in one animal we observed prolonged rectal shedding. Taken together, the rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures.
PMID:32396922DOI:10.1038/s41586-020-2324-7
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
Munster VJ[SUP]1[/SUP], Feldmann F[SUP]2[/SUP], Williamson BN[SUP]1[/SUP], van Doremalen N[SUP]1[/SUP], P?rez-P?rez L[SUP]1[/SUP], Schulz J[SUP]1[/SUP], Meade-White K[SUP]1[/SUP], Okumura A[SUP]1[/SUP], Callison J[SUP]1[/SUP], Brumbaugh B[SUP]3[/SUP], Avanzato VA[SUP]1[/SUP], Rosenke R[SUP]2[/SUP], Hanley PW[SUP]2[/SUP], Saturday G[SUP]2[/SUP], Scott D[SUP]2[/SUP], Fischer ER[SUP]3[/SUP], de Wit E[SUP]4[/SUP].
Author information
Abstract
An outbreak of a novel coronavirus, named SARS-CoV-2, causing respiratory disease and a ~2% case fatality rate started in Wuhan, China in December 2019[SUP]1,2[/SUP]. Following unprecedented global spread[SUP]3[/SUP], the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models, where repeated sampling and tissue collection is possible. Here, we show that SARS-CoV-2 causes respiratory disease in infected rhesus macaques, with disease lasting 8-16 days. Pulmonary infiltrates, a hallmark of human disease, were visible in lung radiographs. High viral loads were detected in swabs from the nose and throat of all animals as well as in bronchoalveolar lavages; in one animal we observed prolonged rectal shedding. Taken together, the rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures.
PMID:32396922DOI:10.1038/s41586-020-2324-7