tetano
Editor, Senior Moderator
Neonatology
. 2022 Feb 25;1-5.
doi: 10.1159/000520537. Online ahead of print.
Neonatal Cerebral Venous Thrombosis following Maternal SARS-CoV-2 Infection in Pregnancy
Francesca Campi[SUP] 1 [/SUP], Daniela Longo[SUP] 2 [/SUP], Iliana Bersani[SUP] 1 [/SUP], Immacolata Savarese[SUP] 1 [/SUP], Giulia Lucignani[SUP] 2 [/SUP], Cristina Haass[SUP] 3 [/SUP], Maria Chiara Paolino[SUP] 3 [/SUP], Sarah Vadalà[SUP] 3 [/SUP], Paola De Liso[SUP] 4 [/SUP], Matteo Di Capua[SUP] 4 [/SUP], Matteo Luciani[SUP] 5 [/SUP], Giacomo Esposito[SUP] 6 [/SUP], Paolina Giuseppina Amante[SUP] 6 [/SUP], Federico Vigevano[SUP] 4 [/SUP], Andrea Dotta[SUP] 1 [/SUP]
Affiliations
Abstract
A possible consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the development of an exacerbated thrombophilic status, and cerebral venous thrombosis (CVT) is a rare but possible complication of SARS-CoV-2 infection reported both in adults and in children. The present case report describes the clinical course of a term neonate showing extended CVT of unclear origin, whose mother had developed SARS-CoV-2 infection during the third trimester of pregnancy. We speculate that the prothrombotic status induced by maternal SARS-CoV-2 infection may have played a pathophysiological role in the development of such severe neonatal complication. Further investigations are required to confirm such hypothesis.
Keywords: Cerebral venous thrombosis; Magnetic resonance imaging; Neonate; Pregnancy; SARS-CoV-2.
. 2022 Feb 25;1-5.
doi: 10.1159/000520537. Online ahead of print.
Neonatal Cerebral Venous Thrombosis following Maternal SARS-CoV-2 Infection in Pregnancy
Francesca Campi[SUP] 1 [/SUP], Daniela Longo[SUP] 2 [/SUP], Iliana Bersani[SUP] 1 [/SUP], Immacolata Savarese[SUP] 1 [/SUP], Giulia Lucignani[SUP] 2 [/SUP], Cristina Haass[SUP] 3 [/SUP], Maria Chiara Paolino[SUP] 3 [/SUP], Sarah Vadalà[SUP] 3 [/SUP], Paola De Liso[SUP] 4 [/SUP], Matteo Di Capua[SUP] 4 [/SUP], Matteo Luciani[SUP] 5 [/SUP], Giacomo Esposito[SUP] 6 [/SUP], Paolina Giuseppina Amante[SUP] 6 [/SUP], Federico Vigevano[SUP] 4 [/SUP], Andrea Dotta[SUP] 1 [/SUP]
Affiliations
- PMID: 35220305
- DOI: 10.1159/000520537
Abstract
A possible consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the development of an exacerbated thrombophilic status, and cerebral venous thrombosis (CVT) is a rare but possible complication of SARS-CoV-2 infection reported both in adults and in children. The present case report describes the clinical course of a term neonate showing extended CVT of unclear origin, whose mother had developed SARS-CoV-2 infection during the third trimester of pregnancy. We speculate that the prothrombotic status induced by maternal SARS-CoV-2 infection may have played a pathophysiological role in the development of such severe neonatal complication. Further investigations are required to confirm such hypothesis.
Keywords: Cerebral venous thrombosis; Magnetic resonance imaging; Neonate; Pregnancy; SARS-CoV-2.