Netherlands: 5th death reported from Tamiflu resistant swine flu

[Gert van der Hoek]

machinetranslated, edited

Swine flu patient resistant to Tamiflu

GRONINGEN - In the University Hospital Groningen a swine flu patient was found to be resistant to the virus inhibitor Tamiflu. This is the first case in the Netherlands. Worldwide, only 32 cases of Tamiflu resistance were found.

The patient was hosptitalised last week in the UMCG. Despite treatment with Tamiflu the swine flu did not disappear, after research the resistance
could be confirmed.

The UMCG with National Institute of Mental Health and Public Health and Environment (RIVM) research to anyone in contact with the patient.
This to avoid spread f the resistant variant .

Tuesday, 03/11/2009

http://www.oogtv.nl/ontwikkelen/php/home.php?subaction=showfull&id=13715

 

[Gert van der Hoek]

Re: Netherlands: First case of swine flu resistance to Tamiflu

Re: Netherlands: First case of swine flu resistance to Tamiflu

google translated

Tamiflu-resistant flu virus did not spread

GRONINGEN - The Tamiflu resistant swine flu virus did not spread , says Jan Wilschut virologist at the University Medical Center Groningen.

Wednesday it was announced that the variant was detected in one patient in the UMCG. The man is in isolation in the intensive care unit of the hospital. He is in stable condition. The man suffers from an immune disorder, so the virus could easily mutate and multiply. By Tamiflu treatment the resistant strain of the virus prevailed. Wilschut expects that the new variant is milder.

The resistance has nothing to do with the vaccination against the Mexican flu. Wilschut press people at heart when they take the vaccine within the target designated by the government fall.

http://www.rtvnoord.nl/nieuws/indexwm.asp?actie=totaalbericht&pid=86328

 

[Gert van der Hoek]

Re: Netherlands: Man dies of Tamiflu resistant swine flu

Re: Netherlands: Man dies of Tamiflu resistant swine flu

Death by resistant influenza virus


In Groningen a deceased man who carried with him a flu virus that was resistant to Tamiflu.

He was one of three patients who are known to have a slightly mutated form of the swine flu .


The man had another serious illness. He was treated in hospital for some time with the
virus inhibitor Tamiflu, to which the virus was resistant. The UMC Groningen says that the resistant
virus did not spread further.

Worldwide, about 50 cases of people with a Mexican resistant flu virus. In
France died last week, two people with such a virus.

http://www.nos.nl/nos/artikelen/2009/12/art000001CA74299B71E76C.html

 

[Celvin11]

Re: Netherlands: Man dies of Tamiflu resistant swine flu

Re: Netherlands: Man dies of Tamiflu resistant swine flu

Netherlands reports mutant swine flu death

http://www.physorg.com/news179059662.html

Netherlands reports mutant swine flu death
December 3, 2009 Dutch authorities said Thursday a patient infected by a mutant strain of the swine flu virus had died.


Harald Wychgel, spokesman for the Dutch Institute for Health and the Environment, told AFP that there had been a "minor change in the virus to make it resistant to Tamiflu," a key treatment for influenza.

"The patient was already seriously ill and being treated for that. He was infected by the Mexican flu and developed a resistance to Tamiflu," Wychgel told AFP.

The Dutch ANP news agency said the man had died in hospital in the northern city of Groningen, adding that two more patients in the Netherlands had shown resistance to Tamiflu.

It is the fifth fatal case of mutated A(H1N1) flu in Europe, after two in France and two in Norway.

The World Health Organisation said last month that a similar mutation had been observed in Brazil, China, Japan, Mexico, where the swine flu pandemic began, Ukraine, and the United States, as early as April.

Italy also reported a non-fatal case on Monday.

"The mutations appear to occur sporadically and spontaneously. To date, no links between the small number of patients infected with the mutated virus have been found and the mutation does not appear to spread," a WHO statement said on November 20.

The WHO also underlined that there was no evidence of more infections or more deaths as a result, while the mutated virus remained sensitive to antiviral drugs used to treat severe flu, oseltamivir (Tamiflu) and zanamivir (Relenza).

Scientists fear that mutations in flu viruses could cause more virulent and deadly pandemic flu. The global health watchdog reiterated a call for close monitoring.

"Although further investigation is under way, no evidence currently suggests that these mutations are leading to an unusual increase in the number of H1N1 infections or a greater number of severe or fatal cases," it added.

(c) 2009 AFP

 

[Gert van der Hoek]

Re: Netherlands: Two die of Tamiflu resistant swine flu

Re: Netherlands: Two die of Tamiflu resistant swine flu

Snip from weekly update RIVM (Dutch CDC) :

6 patients with resistant virus - not related - 2 deaths - no wild virus, but Tamiflu induced resistance - did not spread.

december 4, 2009

Until this week in the Netherlands diagnosed 6 patients, including 3 this week, with a pandemic A (H1N1) influenza virus which is resistant to the anti-viral drug Tamiflu (oseltamivir) that such patients are treated.

In all 6 cases no indication that it is naturally resistant viruses but that resistance has arisen due to the (long) treatment with Tamiflu.

The patients have a prolonged shedding of the influenza virus, in 5 of 6 patients probably due to an impaired immune defenses of these patients.

Two of the patients with underlying disease for which they were treated with chemotherapy are now deceased.

Around the 6 patients have so far no laboratory confirmed cases of transmission of resistant influenza virus found.

http://www.rivm.nl/cib/binaries/H1N1overzicht_tcm92-61018.pdf

 

[Roehl_JC]

Re: Netherlands: Two die of Tamiflu resistant swine flu

Re: Netherlands: Two die of Tamiflu resistant swine flu

Officials in the Netherlands on Thursday announced the first death of a patient with a mutant strain of the swine flu virus, although they said the virus was not attributed to his death.

Harald Wychgel, spokesman for the Dutch Institute for Health and the Environment, told AFP that the virus had undergone minor changes to make it resistant to Tamiflu.

"He died not because the virus was resistant but because he was seriously ill and caught the Mexican (swine) flu," Wychgel said.

We have carried out tests on the patient's associates to see if the mutation had spread but we found no such indications", he said.

Another two patients in the Netherlands have been reported to have a strain of swine flu that is resistant to Tamiflu.

The report marks the fifth fatal case of mutated swine flu in Europe. Two other deaths have been reported in France and two more have been reported in Norway.

According to the World Health Organization, mutated swine flu strains have been reported in Brazil, China, Japan, Mexico, Ukraine, and the United States.

"The mutations appear to occur sporadically and spontaneously. To date, no links between the small number of patients infected with the mutated virus have been found and the mutation does not appear to spread," WHO said in a statement on November 20.

http://www.redorbit.com/news/health/1795223/dutch_patient_with_mutated_swine_flu_strain_dead/

 

[Gert van der Hoek]

Re: Netherlands: Third death reported from Tamiflu resistant swine flu

Re: Netherlands: Third death reported from Tamiflu resistant swine flu

Third death of resistant flu virus

Published: December 8, 2009

BILTHOVEN - A woman from Kaatsheuvel died of a resistant variant of the swine influenza virus.

The National Institute for Health and Environment (RIVM) confirmed
this on tuesday in the Brabants Dagblad.

Meanwhile the RIVM registered three deaths of people with the mutated
flu virus.

All three victims were seriously ill when they got the swine flu,
said one officer of the RIVM.

http://www.nu.nl/binnenland/2139181/derde-sterfgeval-resistent-griepvirus.html

Comment: the cases seem not to be related, only relation is all had a weak immunesytem. Direct contacts were screened, standard protocol.

 

[Shiloh]

Netherlands reports third mutant swine flu death

Netherlands reports third mutant swine flu death

Source: http://www.expatica.com/nl/news/dut...ports-third-mutant-swine-flu-death_58674.html

Netherlands reports third mutant swine flu death
The third victim was a woman suffering from additional ailments.

The Netherlands ? A third person in the Netherlands has died after being infected with a mutant variant of the A(H1N1) flu.

The National Institute for Public Health (RIVM) reports that the woman from Kaatsheuvel in the south of the country was suffering from additional ailments.

Two patients who died earlier were also in poor health and had weakened immune systems. Under such conditions, the virus has more time to mutate and the Tamiflu medication loses its effectiveness.

The original variant of A(H1N1) has taken 42 lives since the flu began to spread in the Netherlands in April. The National Institute for Public Health has classed the epidemic as "mild and dropping in intensity".

The Amphia hospital in the southern city of Breda is disregarding the advice of the Dutch Health Council to inoculate its staff against the fever twice.

The hospital said European research shows that healthy adults are sufficiently protected after a single injection with the vaccine.

Staff who insist on a second jab, however, will be given one, the Amphia added.

The National Institute of Public Health agreed hospitals are free to make their own decisions, but regretted the confusion that may be caused.

The RIVM emphasised that the two-jab rule continues to apply to children and people with health problems who have been called up by their family doctor.

Radio Netherlands / Expatica

 

[Gert van der Hoek]

Re: Netherlands: 4th death reported from Tamiflu resistant swine flu

Re: Netherlands: 4th death reported from Tamiflu resistant swine flu

From today's weekly update:


Until this week were 11 patients diagnosed in the Netherlands, including 5 this week,
with a New Influenza A (H1N1) virus that is resistant to the antiviral agent Tamiflu
(oseltamivir) that such patients are treated.

Four of these patients deceased.

Around the 11 patients have so far no laboratory confirmed cases of transmission
of the resistant influenza virus found.

http://www.rivm.nl/cib/binaries/H1N1overzicht_tcm92-61018.pdf

 

[estacion]

Re: Netherlands - (A) H1N1 - Hospitalisations 2,182 - ICU 209 - Deaths 54

Re: Netherlands - (A) H1N1 - Hospitalisations 2,182 - ICU 209 - Deaths 54

EISS - Weekly Electronic Bulletin
Week 1 : 04/01/2010-10/01/2010 15 January 2010, Issue N? 340
http://www.euroflu.org/cgi-files/bulletin_v2.cgi

Network comments (where available)

Ireland
Please note: 'non-sentinel' specimens recorded as 'A Not Sub-typed' are considered to be probable 'pandemic A (H1N1)' awaiting final confirmation.

Netherlands
By week 2/2010 in the Netherlands 17 patients were diagnosed with oseltamivir resistant pandemic A(H1N1) 2009 influenza virus. Compared to week 1/2010, one additional patient was diagnosed with a mixed population of H275Y oseltamivir resistant and wild-type virus. Thirteen of 15 patients receiving oseltamivir therapy were immunosuppressed due to cytostatic/immunosuppressive therapy, of which five died. One patient with 100% oseltamivir resistent virus population did not receive oseltamivir. Contact tracing identified no cases of onward transmission of the oseltamivir resistant viruses.