tetano
Editor, Senior Moderator
Mycobiology. 2016 Jun;44(2):117-20. doi: 10.5941/MYCO.2016.44.2.117. Epub 2016 Jun 30.
[h=1]Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius.[/h] Kim JY[SUP]1[/SUP], Kim DW[SUP]1[/SUP], Hwang BS[SUP]1[/SUP], Woo EE[SUP]1[/SUP], Lee YJ[SUP]1[/SUP], Jeong KW[SUP]1[/SUP], Lee IK[SUP]1[/SUP], Yun BS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance ((1)H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 ?M.
[h=4]KEYWORDS:[/h] Neuraminidase inhibitor; Phelligridin E; Phelligridin G; Phellinus igniarius
PMID: 27433123 PMCID: PMC4945539 DOI: 10.5941/MYCO.2016.44.2.117
[PubMed] Free PMC Article
[h=1]Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius.[/h] Kim JY[SUP]1[/SUP], Kim DW[SUP]1[/SUP], Hwang BS[SUP]1[/SUP], Woo EE[SUP]1[/SUP], Lee YJ[SUP]1[/SUP], Jeong KW[SUP]1[/SUP], Lee IK[SUP]1[/SUP], Yun BS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance ((1)H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 ?M.
[h=4]KEYWORDS:[/h] Neuraminidase inhibitor; Phelligridin E; Phelligridin G; Phellinus igniarius
PMID: 27433123 PMCID: PMC4945539 DOI: 10.5941/MYCO.2016.44.2.117
[PubMed] Free PMC Article