tetano
Editor, Senior Moderator
Cell Rep. 2013 Apr 17. pii: S2211-1247(13)00158-7. doi: 10.1016/j.celrep.2013.03.034. [Epub ahead of print]
Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses.
Bar-On Y, Glasner A, Meningher T, Achdout H, Gur C, Lankry D, Vitenshtein A, Meyers AF, Mandelboim M, Mandelboim O.
Source
The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.
Abstract
Natural killer (NK) cells play an essential role in the defense against influenza virus, one of the deadliest respiratory viruses known today. The NKp46 receptor, expressed by NK cells, is critical for controlling influenza infections, as influenza-virus-infected cells are eliminated through the recognition of the viral hemagglutinin (HA) protein by NKp46. Here, we describe an immune-evasion mechanism of influenza viruses that is mediated by the neuraminidase (NA) protein. By using various NA blockers, we show that NA removes sialic acid residues from NKp46 and that this leads to reduced recognition of HA. Furthermore, we provide in vivo and in vitro evidence for the existence of this NA-mediated, NKp46-dependent immune-evasion mechanism and demonstrate that NA inhibitors, which are commonly used for the treatment of influenza infections, are useful not only as blockers of virus budding but also as boosters of NKp46 recognition.
Copyright ? 2013 The Authors. Published by Elsevier Inc. All rights reserved.
PMID:
23602571
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23602571
Neuraminidase-Mediated, NKp46-Dependent Immune-Evasion Mechanism of Influenza Viruses.
Bar-On Y, Glasner A, Meningher T, Achdout H, Gur C, Lankry D, Vitenshtein A, Meyers AF, Mandelboim M, Mandelboim O.
Source
The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel.
Abstract
Natural killer (NK) cells play an essential role in the defense against influenza virus, one of the deadliest respiratory viruses known today. The NKp46 receptor, expressed by NK cells, is critical for controlling influenza infections, as influenza-virus-infected cells are eliminated through the recognition of the viral hemagglutinin (HA) protein by NKp46. Here, we describe an immune-evasion mechanism of influenza viruses that is mediated by the neuraminidase (NA) protein. By using various NA blockers, we show that NA removes sialic acid residues from NKp46 and that this leads to reduced recognition of HA. Furthermore, we provide in vivo and in vitro evidence for the existence of this NA-mediated, NKp46-dependent immune-evasion mechanism and demonstrate that NA inhibitors, which are commonly used for the treatment of influenza infections, are useful not only as blockers of virus budding but also as boosters of NKp46 recognition.
Copyright ? 2013 The Authors. Published by Elsevier Inc. All rights reserved.
PMID:
23602571
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23602571