tetano
Editor, Senior Moderator
Neurol Sci
. 2024 Jan 3.
doi: 10.1007/s10072-023-07279-6. Online ahead of print. COVID-19-associated serum and cerebrospinal fluid cytokines in post- versus para-infectious SARS-CoV-2-related Guillain-Barré syndrome
Federico Massa[SUP] 1 2 [/SUP], Tiziana Vigo[SUP] 3 [/SUP], Margherita Bellucci[SUP] 4 [/SUP], Debora Giunti[SUP] 4 3 [/SUP], Maria Mobilia Emanuela[SUP] 3 [/SUP], Davide Visigalli[SUP] 4 3 [/SUP], Giovanna Capodivento[SUP] 4 3 [/SUP], Denise Cerne[SUP] 4 [/SUP], Andrea Assini[SUP] 5 [/SUP], Silvia Boni[SUP] 6 [/SUP], Domenica Rizzi[SUP] 7 [/SUP], Eleonora Narciso[SUP] 8 [/SUP], Giuseppe Stefano Grisanti[SUP] 9 [/SUP], Elena Coco[SUP] 9 [/SUP], Antonio Uccelli[SUP] 4 3 [/SUP], Angelo Schenone[SUP] 4 3 [/SUP], Diego Franciotta[SUP] 10 [/SUP], Luana Benedetti[SUP] 4 3 [/SUP]
Affiliations
Introduction: Guillain-Barré syndrome associated with Coronavirus-2-related severe acute respiratory syndrome (COV-GBS) occurs as para- or post-infectious forms, depending on the timing of disease onset. In these two forms, we aimed to compare the cerebrospinal fluid (CSF) and serum proinflammatory cytokine profiles to evaluate differences that could possibly have co-pathogenic relevance.
Materials and methods: We studied a retrospective cohort of 26 patients with either post-COV-GBS (n = 15), with disease onset occurring > 7 days after SARS-CoV-2 infection, or para-COV-GBS (n = 11), with disease onset 7 days or less. TNF-α, IL-6, and IL-8 were measured in the serum with SimplePlex™ Ella™ immunoassay. In addition to the para-/post-COV-GBS patients, serum levels of these cytokines were determined in those with non-COVID-associated-GBS (NC-GBS; n = 43), paucisymptomatic SARS-CoV-2 infection without GBS (COVID, n = 20), and in healthy volunteers (HV; n = 12). CSF cytokine levels were measured in patients with para-/post-COV-GBS, in those with NC-GBS (n = 29), or with Alzheimer's disease (AD; n = 24).
Results: Serum/CSF cytokine levels did not differ in para- vs post-COV-GBS. We found that SARS-CoV-2 infection raises the serum levels of TNF-α, IL-6, and IL-8, as well as an increase of IL-6 (in serum and CSF) and IL-8 (in CSF) in either NC-GBS or COV-GBS than controls. CSF and serum cytokine levels resulted independent one with another.
Conclusions: The change of cytokines linked to SARS-CoV-2 in COV-GBS appears to be driven by viral infection, although it has unique characteristics in GBS as such and does not account for cases with para- or post-infectious onset.
Keywords: COVID-19; Cytokines; Guillain–Barré syndrome; Neuroinflammation.
. 2024 Jan 3.
doi: 10.1007/s10072-023-07279-6. Online ahead of print. COVID-19-associated serum and cerebrospinal fluid cytokines in post- versus para-infectious SARS-CoV-2-related Guillain-Barré syndrome
Federico Massa[SUP] 1 2 [/SUP], Tiziana Vigo[SUP] 3 [/SUP], Margherita Bellucci[SUP] 4 [/SUP], Debora Giunti[SUP] 4 3 [/SUP], Maria Mobilia Emanuela[SUP] 3 [/SUP], Davide Visigalli[SUP] 4 3 [/SUP], Giovanna Capodivento[SUP] 4 3 [/SUP], Denise Cerne[SUP] 4 [/SUP], Andrea Assini[SUP] 5 [/SUP], Silvia Boni[SUP] 6 [/SUP], Domenica Rizzi[SUP] 7 [/SUP], Eleonora Narciso[SUP] 8 [/SUP], Giuseppe Stefano Grisanti[SUP] 9 [/SUP], Elena Coco[SUP] 9 [/SUP], Antonio Uccelli[SUP] 4 3 [/SUP], Angelo Schenone[SUP] 4 3 [/SUP], Diego Franciotta[SUP] 10 [/SUP], Luana Benedetti[SUP] 4 3 [/SUP]
Affiliations
- PMID: 38169013
- DOI: 10.1007/s10072-023-07279-6
Introduction: Guillain-Barré syndrome associated with Coronavirus-2-related severe acute respiratory syndrome (COV-GBS) occurs as para- or post-infectious forms, depending on the timing of disease onset. In these two forms, we aimed to compare the cerebrospinal fluid (CSF) and serum proinflammatory cytokine profiles to evaluate differences that could possibly have co-pathogenic relevance.
Materials and methods: We studied a retrospective cohort of 26 patients with either post-COV-GBS (n = 15), with disease onset occurring > 7 days after SARS-CoV-2 infection, or para-COV-GBS (n = 11), with disease onset 7 days or less. TNF-α, IL-6, and IL-8 were measured in the serum with SimplePlex™ Ella™ immunoassay. In addition to the para-/post-COV-GBS patients, serum levels of these cytokines were determined in those with non-COVID-associated-GBS (NC-GBS; n = 43), paucisymptomatic SARS-CoV-2 infection without GBS (COVID, n = 20), and in healthy volunteers (HV; n = 12). CSF cytokine levels were measured in patients with para-/post-COV-GBS, in those with NC-GBS (n = 29), or with Alzheimer's disease (AD; n = 24).
Results: Serum/CSF cytokine levels did not differ in para- vs post-COV-GBS. We found that SARS-CoV-2 infection raises the serum levels of TNF-α, IL-6, and IL-8, as well as an increase of IL-6 (in serum and CSF) and IL-8 (in CSF) in either NC-GBS or COV-GBS than controls. CSF and serum cytokine levels resulted independent one with another.
Conclusions: The change of cytokines linked to SARS-CoV-2 in COV-GBS appears to be driven by viral infection, although it has unique characteristics in GBS as such and does not account for cases with para- or post-infectious onset.
Keywords: COVID-19; Cytokines; Guillain–Barré syndrome; Neuroinflammation.