tetano
Editor, Senior Moderator
Pediatr Int. 2012 Feb 2. doi: 10.1111/j.1442-200X.2012.03568.x. [Epub ahead of print]
Neurologic adverse events following influenza A (H1N1) vaccinations in children.
Lee SJ, Kim YO, Woo YJ, Kim MK, Nam TS, Cho YK.
Source
Department of Pediatrics and Neurology, School of Medicine, Chonnam National University, Gwangju, Korea.
Abstract
Background: Since the monovalent pandemic influenza A (H1N1) vaccine was recommended world-wide in October 2009, there is still a shortage of pediatric clinical data for post-vaccine neurologic adverse events (NAE) including Guillain-Barr? syndrome (GBS). We reviewed pediatric NAE data following H1N1 vaccinations and for patients with peripheral neuropathy followed their progress. Methods: In our single center study, we retrospectively reviewed 14 cases of children who visited the division of pediatric neurology in the department of pediatrics of Chonnam National University Hospital due to an NAE following monovalent influenza A (H1N1) vaccination between November 2009 and March 2010. Results: Clinical diagnoses for major NAEs included: poly-neuropathy in the extremities (11/14, 78.6%), sensory mono-neuropathy with numbness in the left fibula area (1/14, 7.1%), Bell's palsy (1/14, 7.1%) and recent-onset acute headache only (1/14, 7.1%). Therefore, most patients were diagnosed as having peripheral neuropathy (13/14, 92.9%), of which two met the Brighton Collaboration GBS definition criteria for level 3 (the lowest level of diagnostic certainty). Conclusions: Post-vaccine NAEs were mainly motor weakness due to poly-neuropathy, which had a good prognosis of complete improvement within a few months without sequelae. ? 2012 The Authors. Pediatrics International ? 2012 Japan Pediatric Society.
? 2012 The Authors. Pediatrics International ? 2012 Japan Pediatric Society.
PMID:
22299607
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22299607
Neurologic adverse events following influenza A (H1N1) vaccinations in children.
Lee SJ, Kim YO, Woo YJ, Kim MK, Nam TS, Cho YK.
Source
Department of Pediatrics and Neurology, School of Medicine, Chonnam National University, Gwangju, Korea.
Abstract
Background: Since the monovalent pandemic influenza A (H1N1) vaccine was recommended world-wide in October 2009, there is still a shortage of pediatric clinical data for post-vaccine neurologic adverse events (NAE) including Guillain-Barr? syndrome (GBS). We reviewed pediatric NAE data following H1N1 vaccinations and for patients with peripheral neuropathy followed their progress. Methods: In our single center study, we retrospectively reviewed 14 cases of children who visited the division of pediatric neurology in the department of pediatrics of Chonnam National University Hospital due to an NAE following monovalent influenza A (H1N1) vaccination between November 2009 and March 2010. Results: Clinical diagnoses for major NAEs included: poly-neuropathy in the extremities (11/14, 78.6%), sensory mono-neuropathy with numbness in the left fibula area (1/14, 7.1%), Bell's palsy (1/14, 7.1%) and recent-onset acute headache only (1/14, 7.1%). Therefore, most patients were diagnosed as having peripheral neuropathy (13/14, 92.9%), of which two met the Brighton Collaboration GBS definition criteria for level 3 (the lowest level of diagnostic certainty). Conclusions: Post-vaccine NAEs were mainly motor weakness due to poly-neuropathy, which had a good prognosis of complete improvement within a few months without sequelae. ? 2012 The Authors. Pediatrics International ? 2012 Japan Pediatric Society.
? 2012 The Authors. Pediatrics International ? 2012 Japan Pediatric Society.
PMID:
22299607
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22299607