Mary Wilson
Well-known member
Published:July 14, 2021
DOI:https://doi.org/10.1016/S2352-4642(21)00193-0
Stephen T J Ray, Omar Abdel-Mannan, Mario Sa, Charlotte Fuller, Greta K Wood, Karen Pysden, Michael Yoong, Helen McCullagh, David Scott, Martin McMahon, Naomi Thomas, Micheal Taylor, Marjorie Illingworth, Nadine McCrea, Victoria Davies, William Whitehouse, Sameer Zuberi, Keira Guthrie, Evangeline Wassmer, Nikit Shah, Mark R Baker, Sangeeta Tiwary, Hui Jeen Tan, Uma Varma, Dipak Ram, Shivaram Avula, Noelle Enright, Jane Hassell, Amy L Ross Russell, Ram Kumar, Rachel E Mulholland, Sarah Pett, Ian Galea, Rhys H Thomas, Ming Lim, Yael Hacohen, Tom Solomon*, Michael J Gri ths*, Benedict D Michael*, Rachel Kneen*, on behalf of the CoroNerve study group†
Summary
Background The spectrum of neurological and psychiatric complications associated with paediatric SARS-CoV-2 infection is poorly understood. We aimed to analyse the range and prevalence of these complications in hospitalised children and adolescents.
Methods
We did a prospective national cohort study in the UK using an online network of secure rapid-response noti cation portals established by the CoroNerve study group. Paediatric neurologists were invited to notify any children and adolescents (age <18 years) admitted to hospital with neurological or psychiatric disorders in whom they considered SARS-CoV-2 infection to be relevant to the presentation. Patients were excluded if they did not have a neurological consultation or neurological investigations or both, or did not meet the de nition for con rmed SARS-CoV-2 infection (a positive PCR of respiratory or spinal uid samples, serology for anti-SARS-CoV-2 IgG, or both), or the Royal College of Paediatrics and Child Health criteria for paediatric in ammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Individuals were classi ed as having either a primary neurological disorder associated with COVID-19 (COVID-19 neurology group) or PIMS-TS with neurological features (PIMS-TS neurology group). The denominator of all hospitalised children and adolescents with COVID-19 was collated from National Health Service England data.
...
https://www.thelancet.com/action/showPdf?pii=S2352-4642(21)00193-0
DOI:https://doi.org/10.1016/S2352-4642(21)00193-0
Stephen T J Ray, Omar Abdel-Mannan, Mario Sa, Charlotte Fuller, Greta K Wood, Karen Pysden, Michael Yoong, Helen McCullagh, David Scott, Martin McMahon, Naomi Thomas, Micheal Taylor, Marjorie Illingworth, Nadine McCrea, Victoria Davies, William Whitehouse, Sameer Zuberi, Keira Guthrie, Evangeline Wassmer, Nikit Shah, Mark R Baker, Sangeeta Tiwary, Hui Jeen Tan, Uma Varma, Dipak Ram, Shivaram Avula, Noelle Enright, Jane Hassell, Amy L Ross Russell, Ram Kumar, Rachel E Mulholland, Sarah Pett, Ian Galea, Rhys H Thomas, Ming Lim, Yael Hacohen, Tom Solomon*, Michael J Gri ths*, Benedict D Michael*, Rachel Kneen*, on behalf of the CoroNerve study group†
Summary
Background The spectrum of neurological and psychiatric complications associated with paediatric SARS-CoV-2 infection is poorly understood. We aimed to analyse the range and prevalence of these complications in hospitalised children and adolescents.
Methods
We did a prospective national cohort study in the UK using an online network of secure rapid-response noti cation portals established by the CoroNerve study group. Paediatric neurologists were invited to notify any children and adolescents (age <18 years) admitted to hospital with neurological or psychiatric disorders in whom they considered SARS-CoV-2 infection to be relevant to the presentation. Patients were excluded if they did not have a neurological consultation or neurological investigations or both, or did not meet the de nition for con rmed SARS-CoV-2 infection (a positive PCR of respiratory or spinal uid samples, serology for anti-SARS-CoV-2 IgG, or both), or the Royal College of Paediatrics and Child Health criteria for paediatric in ammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). Individuals were classi ed as having either a primary neurological disorder associated with COVID-19 (COVID-19 neurology group) or PIMS-TS with neurological features (PIMS-TS neurology group). The denominator of all hospitalised children and adolescents with COVID-19 was collated from National Health Service England data.
...
https://www.thelancet.com/action/showPdf?pii=S2352-4642(21)00193-0