tetano
Editor, Senior Moderator
Neuropediatrics
. 2021 Jul 29.
doi: 10.1055/s-0041-1732364. Online ahead of print.
Longitudinally Extensive Transverse Myelitis (LETM) and Myopericarditis in a 7-Month-Old Child with SARs-CoV-2 Infection
Giacomo Brisca[SUP] 1 [/SUP], Stefano Sotgiu[SUP] 2 [/SUP], Daniela Pirlo[SUP] 1 [/SUP], Barbara Tubino[SUP] 3 [/SUP], Laura Siri[SUP] 4 [/SUP], Benedetta Chianucci[SUP] 5 [/SUP], Alessandra Carta[SUP] 2 [/SUP], Andrea Rossi[SUP] 6 7 [/SUP], Marisa Mallamaci[SUP] 1 [/SUP], Matteo Cataldi[SUP] 4 [/SUP], Maria Margherita Mancardi[SUP] 4 [/SUP]
Affiliations
Abstract
Introduction: In the last few months, some pediatric cases with neurological and neuroradiological pictures related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported, often associated with multisystem inflammatory syndrome (MIS-C). The most frequently encountered pediatric neurological complications seem to be postinfectious immune-mediated acute disseminated encephalomyelitis (ADEM)-like changes of the brain, myelitis, neural enhancement, and splenial lesions. Concomitant neurological and cardiac involvement has been reported only in MIS-C, although specific clinical details are often not fully available.
Methods: In this case report, a very young child infected with SARs-CoV-2 and diagnosed as longitudinal extensive transverse myelitis with concomitant myo-pericarditis is presented.
Results: A previously healthy 7-month-old girl presented with abrupt onset of generalized weakness with inability to sit up. She had had mild respiratory symptoms 1 week earlier. Spinal magnetic resonance imaging (MRI) showed a T2-hyperintense intramedullary lesion extending from C4 to T2, compatible with acute longitudinally extensive transverse myelitis (LETM). Cerebrospinal fluid analysis was negative.Echocardiography and blood tests were suggestive for myo-pericarditis. Real time polymerase chain reaction for SARS-CoV-2 on nasopharyngeal swab sample tested positive. She was promptly treated with high dose of steroids and immunoglobulin with satisfactory clinical response.
Conclusion: To the evolving literature of neurological complications of SARs-CoV-2 infection, we add the youngest patient described to date with isolated LETM and concomitant cardiac involvement. Our case suggests that clinicians should be aware of this association, although difficult to recognize in infants. Practitioners are encouraged to consider aggressive first-line immunotherapies with the final aim to prevent permanent disability.
. 2021 Jul 29.
doi: 10.1055/s-0041-1732364. Online ahead of print.
Longitudinally Extensive Transverse Myelitis (LETM) and Myopericarditis in a 7-Month-Old Child with SARs-CoV-2 Infection
Giacomo Brisca[SUP] 1 [/SUP], Stefano Sotgiu[SUP] 2 [/SUP], Daniela Pirlo[SUP] 1 [/SUP], Barbara Tubino[SUP] 3 [/SUP], Laura Siri[SUP] 4 [/SUP], Benedetta Chianucci[SUP] 5 [/SUP], Alessandra Carta[SUP] 2 [/SUP], Andrea Rossi[SUP] 6 7 [/SUP], Marisa Mallamaci[SUP] 1 [/SUP], Matteo Cataldi[SUP] 4 [/SUP], Maria Margherita Mancardi[SUP] 4 [/SUP]
Affiliations
- PMID: 34327697
- DOI: 10.1055/s-0041-1732364
Abstract
Introduction: In the last few months, some pediatric cases with neurological and neuroradiological pictures related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have been reported, often associated with multisystem inflammatory syndrome (MIS-C). The most frequently encountered pediatric neurological complications seem to be postinfectious immune-mediated acute disseminated encephalomyelitis (ADEM)-like changes of the brain, myelitis, neural enhancement, and splenial lesions. Concomitant neurological and cardiac involvement has been reported only in MIS-C, although specific clinical details are often not fully available.
Methods: In this case report, a very young child infected with SARs-CoV-2 and diagnosed as longitudinal extensive transverse myelitis with concomitant myo-pericarditis is presented.
Results: A previously healthy 7-month-old girl presented with abrupt onset of generalized weakness with inability to sit up. She had had mild respiratory symptoms 1 week earlier. Spinal magnetic resonance imaging (MRI) showed a T2-hyperintense intramedullary lesion extending from C4 to T2, compatible with acute longitudinally extensive transverse myelitis (LETM). Cerebrospinal fluid analysis was negative.Echocardiography and blood tests were suggestive for myo-pericarditis. Real time polymerase chain reaction for SARS-CoV-2 on nasopharyngeal swab sample tested positive. She was promptly treated with high dose of steroids and immunoglobulin with satisfactory clinical response.
Conclusion: To the evolving literature of neurological complications of SARs-CoV-2 infection, we add the youngest patient described to date with isolated LETM and concomitant cardiac involvement. Our case suggests that clinicians should be aware of this association, although difficult to recognize in infants. Practitioners are encouraged to consider aggressive first-line immunotherapies with the final aim to prevent permanent disability.