tetano
Editor, Senior Moderator
Neuroscience
. 2024 Nov 30:S0306-4522(24)00623-7.
doi: 10.1016/j.neuroscience.2024.11.036. Online ahead of print. Risk factors for delirium in patients with COVID-19: A systematic review and meta-analysis
Ziying Wen[SUP] 1 [/SUP], Rui Ma[SUP] 2 [/SUP], Jia Chen[SUP] 1 [/SUP], Yujie Deng[SUP] 2 [/SUP], Huan Li[SUP] 2 [/SUP], Boyong Huang[SUP] 2 [/SUP], Fengxia Han[SUP] 2 [/SUP], Cui Li[SUP] 2 [/SUP], Yang Chen[SUP] 2 [/SUP], Hao Wang[SUP] 2 [/SUP], Sean X Leng[SUP] 3 [/SUP], Shiren Sun[SUP] 4 [/SUP], Xiaoxuan Ning[SUP] 5 [/SUP]
Affiliations
Delirium is one of the serious neurological complications of Coronavirus Disease 2019 (COVID-19) and is associated with significant morbidity and mortality in patients with COVID-19, especially in older patients. There is currently no meta-analysis of risk factors for delirium in patients with COVID-19. This study aimed to identify potential risk factors for delirium in patients with COVID-19 through a meta-analysis of observational clinical studies. In conducting this analysis, literature searches were conducted in PubMed, Embase, Cochrane Library, and Web of Science, and study quality was assessed using the Newcastle-Ottawa Quality Scale (NOS). Data were extracted independently by two reviewers and pooled using either fixed effects or random effects models based on the results of heterogeneity testing. As a result of this meta-analysis, a total of 21 studies were included, including 10,147 patients. The analysis revealed the identification of 26 predisposing factors and 54 precipitating factors associated with COVID-19-related delirium. Notably, the administration of hydrocortisone and azithromycin, among other specific medications designated for COVID-19, exhibited a potential to be positively associated with the incidence of delirium in patients afflicted with COVID-19. In conclusion, the present study identified potential predisposing and precipitating factors linked with delirium in COVID-19 patients. It is anticipated that these results will have a considerable impact on the management and treatment of delirium in COVID-19 patients.
Keywords: COVID-19; Delirium; Meta-analysis; Review; Risk factors.
. 2024 Nov 30:S0306-4522(24)00623-7.
doi: 10.1016/j.neuroscience.2024.11.036. Online ahead of print. Risk factors for delirium in patients with COVID-19: A systematic review and meta-analysis
Ziying Wen[SUP] 1 [/SUP], Rui Ma[SUP] 2 [/SUP], Jia Chen[SUP] 1 [/SUP], Yujie Deng[SUP] 2 [/SUP], Huan Li[SUP] 2 [/SUP], Boyong Huang[SUP] 2 [/SUP], Fengxia Han[SUP] 2 [/SUP], Cui Li[SUP] 2 [/SUP], Yang Chen[SUP] 2 [/SUP], Hao Wang[SUP] 2 [/SUP], Sean X Leng[SUP] 3 [/SUP], Shiren Sun[SUP] 4 [/SUP], Xiaoxuan Ning[SUP] 5 [/SUP]
Affiliations
- PMID: 39622382
- DOI: 10.1016/j.neuroscience.2024.11.036
Delirium is one of the serious neurological complications of Coronavirus Disease 2019 (COVID-19) and is associated with significant morbidity and mortality in patients with COVID-19, especially in older patients. There is currently no meta-analysis of risk factors for delirium in patients with COVID-19. This study aimed to identify potential risk factors for delirium in patients with COVID-19 through a meta-analysis of observational clinical studies. In conducting this analysis, literature searches were conducted in PubMed, Embase, Cochrane Library, and Web of Science, and study quality was assessed using the Newcastle-Ottawa Quality Scale (NOS). Data were extracted independently by two reviewers and pooled using either fixed effects or random effects models based on the results of heterogeneity testing. As a result of this meta-analysis, a total of 21 studies were included, including 10,147 patients. The analysis revealed the identification of 26 predisposing factors and 54 precipitating factors associated with COVID-19-related delirium. Notably, the administration of hydrocortisone and azithromycin, among other specific medications designated for COVID-19, exhibited a potential to be positively associated with the incidence of delirium in patients afflicted with COVID-19. In conclusion, the present study identified potential predisposing and precipitating factors linked with delirium in COVID-19 patients. It is anticipated that these results will have a considerable impact on the management and treatment of delirium in COVID-19 patients.
Keywords: COVID-19; Delirium; Meta-analysis; Review; Risk factors.