tetano
Editor, Senior Moderator
Virology. 2016 Apr 22;494:143-157. doi: 10.1016/j.virol.2016.01.024. [Epub ahead of print]
[h=1]Neutralizing inhibitors in the airways of na?ve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses.[/h] Job ER[SUP]1[/SUP], Pizzolla A[SUP]1[/SUP], Nebl T[SUP]2[/SUP], Short KR[SUP]1[/SUP], Deng YM[SUP]3[/SUP], Carolan L[SUP]3[/SUP], Laurie KL[SUP]3[/SUP], Brooks AG[SUP]1[/SUP], Reading PC[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Many insights regarding the pathogenesis of human influenza A virus (IAV) infections have come from studies in mice and ferrets. Surfactant protein (SP)-D is the major neutralizing inhibitor of IAV in mouse airway fluids and SP-D-resistant IAV mutants show enhanced virus replication and virulence in mice. Herein, we demonstrate that sialylated glycoproteins, rather than SP-D, represent the major neutralizing inhibitors against H3 subtype viruses in airway fluids from na?ve ferrets. Moreover, while resistance to neutralizing inhibitors is a critical factor in modulating virus replication and disease in the mouse model, it does not appear to be so in the ferret model, as H3 mutants resistant to either SP-D or sialylated glycoproteins in ferret airway fluids did not show enhanced virulence in ferrets. These data have important implications for our understanding of pathogenesis and immunity to human IAV infections in these two widely used animal models of infection.
Copyright ? 2016. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Animal model; Influenza; Innate; Lectin; Surfactant; Virulence
PMID: 27110707 [PubMed - as supplied by publisher]
[h=1]Neutralizing inhibitors in the airways of na?ve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses.[/h] Job ER[SUP]1[/SUP], Pizzolla A[SUP]1[/SUP], Nebl T[SUP]2[/SUP], Short KR[SUP]1[/SUP], Deng YM[SUP]3[/SUP], Carolan L[SUP]3[/SUP], Laurie KL[SUP]3[/SUP], Brooks AG[SUP]1[/SUP], Reading PC[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Many insights regarding the pathogenesis of human influenza A virus (IAV) infections have come from studies in mice and ferrets. Surfactant protein (SP)-D is the major neutralizing inhibitor of IAV in mouse airway fluids and SP-D-resistant IAV mutants show enhanced virus replication and virulence in mice. Herein, we demonstrate that sialylated glycoproteins, rather than SP-D, represent the major neutralizing inhibitors against H3 subtype viruses in airway fluids from na?ve ferrets. Moreover, while resistance to neutralizing inhibitors is a critical factor in modulating virus replication and disease in the mouse model, it does not appear to be so in the ferret model, as H3 mutants resistant to either SP-D or sialylated glycoproteins in ferret airway fluids did not show enhanced virulence in ferrets. These data have important implications for our understanding of pathogenesis and immunity to human IAV infections in these two widely used animal models of infection.
Copyright ? 2016. Published by Elsevier Inc.
[h=4]KEYWORDS:[/h] Animal model; Influenza; Innate; Lectin; Surfactant; Virulence
PMID: 27110707 [PubMed - as supplied by publisher]