Shiloh
Editor, Senior Moderator
Source: http://www.sciencedaily.com/releases/2013/06/130618113654.htm
New Approach to Battling Tuberculosis
June 18, 2013 ? Most humans would like to shed their fatty exteriors, but tuberculosis (TB)-causing bacteria rely on theirs for survival. Scientists at the University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School have now discovered a drug that cripples the TB bug by dissolving its protective fatty coating, a finding that could eventually be used to improve TB treatment in humans. The study has been posted online by Nature Chemical Biology...
...Journal Reference:
Regina Wilson, Pradeep Kumar, Vijay Parashar, Catherine Vilch?ze, Romain Veyron-Churlet, Joel S Freundlich, S Whitney Barnes, John R Walker, Michael J Szymonifka, Emily Marchiano, Shubhada Shenai, Roberto Colangeli, William R Jacobs, Matthew B Neiditch, Laurent Kremer, David Alland. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature Chemical Biology, 2013; DOI: 10.1038/nchembio.1277
New Approach to Battling Tuberculosis
June 18, 2013 ? Most humans would like to shed their fatty exteriors, but tuberculosis (TB)-causing bacteria rely on theirs for survival. Scientists at the University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School have now discovered a drug that cripples the TB bug by dissolving its protective fatty coating, a finding that could eventually be used to improve TB treatment in humans. The study has been posted online by Nature Chemical Biology...
...Journal Reference:
Regina Wilson, Pradeep Kumar, Vijay Parashar, Catherine Vilch?ze, Romain Veyron-Churlet, Joel S Freundlich, S Whitney Barnes, John R Walker, Michael J Szymonifka, Emily Marchiano, Shubhada Shenai, Roberto Colangeli, William R Jacobs, Matthew B Neiditch, Laurent Kremer, David Alland. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature Chemical Biology, 2013; DOI: 10.1038/nchembio.1277