New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1)

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Bull Exp Biol Med. 2016 Jul 7. [Epub ahead of print]
[h=1]New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1).[/h] Shibnev VA[SUP]1[/SUP], Garaev TM[SUP]2[/SUP], Deryabin PG[SUP]1[/SUP], Finogenova MP[SUP]1[/SUP], Botikov AG[SUP]1[/SUP], Mishin DV[SUP]1[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.


[h=4]KEYWORDS:[/h] adamantane derivatives; amino acids; antiviral activity; influenza A/H5N1 virus; remantadine

PMID: 27383164 DOI: 10.1007/s10517-016-3396-0
[PubMed - as supplied by publisher]