tetano
Editor, Senior Moderator
New Microbes New Infect
. 2020 Jul 23;37:100732.
doi: 10.1016/j.nmni.2020.100732. eCollection 2020 Sep.
COVID-19 infection recurrence presenting with meningoencephalitis
M Mardani[SUP] 1 [/SUP], S Alireza Nadji[SUP] 2 [/SUP], K Aghazadeh Sarhangipor[SUP] 3 [/SUP], A Sharifi-Razavi[SUP] 4 [/SUP], M Baziboroun[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) infection can involve many organs, such as central nervous system, including in relapse. We describe the case of a 64-year-old woman with microbiologically confirmed COVID-19-induced respiratory distress whose treatment resulted in a negative nasopharyngeal swab reverse transcriptase PCR (RT-PCR) result for COVID-19. However, after a few weeks, relapse occurred, as indicated by symptoms of acute meningoencephalitis. Results of COVID-19 RT-PCR testing from her cerebrospinal fluid, nasopharyngeal and tracheal aspiration specimens became positive again, but COVID-19 serum antibodies were negative. We therefore note that symptoms with neurologic involvement can be one of COVID-19's first presentations, or they can appear at relapse. Regular evaluation of patients during convalescence is therefore necessary.
Keywords: COVID-19; Encephalitis; Meningitis; Nervous system; Recurrence.
. 2020 Jul 23;37:100732.
doi: 10.1016/j.nmni.2020.100732. eCollection 2020 Sep.
COVID-19 infection recurrence presenting with meningoencephalitis
M Mardani[SUP] 1 [/SUP], S Alireza Nadji[SUP] 2 [/SUP], K Aghazadeh Sarhangipor[SUP] 3 [/SUP], A Sharifi-Razavi[SUP] 4 [/SUP], M Baziboroun[SUP] 1 [/SUP]
Affiliations
- PMID: 32789020
- PMCID: PMC7376341
- DOI: 10.1016/j.nmni.2020.100732
Abstract
Coronavirus disease 2019 (COVID-19) infection can involve many organs, such as central nervous system, including in relapse. We describe the case of a 64-year-old woman with microbiologically confirmed COVID-19-induced respiratory distress whose treatment resulted in a negative nasopharyngeal swab reverse transcriptase PCR (RT-PCR) result for COVID-19. However, after a few weeks, relapse occurred, as indicated by symptoms of acute meningoencephalitis. Results of COVID-19 RT-PCR testing from her cerebrospinal fluid, nasopharyngeal and tracheal aspiration specimens became positive again, but COVID-19 serum antibodies were negative. We therefore note that symptoms with neurologic involvement can be one of COVID-19's first presentations, or they can appear at relapse. Regular evaluation of patients during convalescence is therefore necessary.
Keywords: COVID-19; Encephalitis; Meningitis; Nervous system; Recurrence.