tetano
Editor, Senior Moderator
Bioorg Med Chem. 2013 Aug 12. pii: S0968-0896(13)00696-2. doi: 10.1016/j.bmc.2013.08.014. [Epub ahead of print]
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity.
Sokolova AS, Yarovaya CO, Shernyukov CA, Pokrovsky CE, Pokrovsky CA, Lavrinenko VA, Zarubaev VV, Tretiak TS, Anfimov PM, Kiselev OI, Beklemishev AB, Salakhutdinov NF.
Source
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
Abstract
The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Antivirals, Camphor, Cytotoxicity, Genotoxicity, Imine derivatives, Influenza
PMID:
23993669
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23993669
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity.
Sokolova AS, Yarovaya CO, Shernyukov CA, Pokrovsky CE, Pokrovsky CA, Lavrinenko VA, Zarubaev VV, Tretiak TS, Anfimov PM, Kiselev OI, Beklemishev AB, Salakhutdinov NF.
Source
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Lavrentjev Avenue 9, 630090 Novosibirsk, Russia; Novosibirsk State University, Pirogova St. 2, 630090 Novosibirsk, Russia.
Abstract
The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.
Copyright ? 2013. Published by Elsevier Ltd.
KEYWORDS:
Antivirals, Camphor, Cytotoxicity, Genotoxicity, Imine derivatives, Influenza
PMID:
23993669
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23993669