tetano
Editor, Senior Moderator
J Antibiot (Tokyo). 2013 Dec 11. doi: 10.1038/ja.2013.135. [Epub ahead of print]
New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925.
Zhu T, Chen Z, Liu P, Wang Y, Xin Z, Zhu W.
Source
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Abstract
Two new rubrolides, rubrolides R (1) and S (2), were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus OUCMDZ-1925. Their structures were elucidated on the basis of spectroscopic analysis and X-ray single crystal diffraction. Compound 1 showed comparable or superior antioxidation against 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals to those of trolox and ascorbic acid with an IC50 value of 1.33 mM. Compound 2 showed comparable or superior anti-influenza A (H1N1) virus activity to that of ribavirin with an IC50 value of 87.1 μM. Both compounds 1 and 2 showed weak cytotoxicity against the K562 cell line with IC50 values of 12.8 and 10.9 μM, respectively.The Journal of Antibiotics advance online publication, 11 December 2013; doi:10.1038/ja.2013.135.
PMID:
24326339
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24326339
New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925.
Zhu T, Chen Z, Liu P, Wang Y, Xin Z, Zhu W.
Source
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Abstract
Two new rubrolides, rubrolides R (1) and S (2), were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus OUCMDZ-1925. Their structures were elucidated on the basis of spectroscopic analysis and X-ray single crystal diffraction. Compound 1 showed comparable or superior antioxidation against 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals to those of trolox and ascorbic acid with an IC50 value of 1.33 mM. Compound 2 showed comparable or superior anti-influenza A (H1N1) virus activity to that of ribavirin with an IC50 value of 87.1 μM. Both compounds 1 and 2 showed weak cytotoxicity against the K562 cell line with IC50 values of 12.8 and 10.9 μM, respectively.The Journal of Antibiotics advance online publication, 11 December 2013; doi:10.1038/ja.2013.135.
PMID:
24326339
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24326339