tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2016 Jan 4. pii: AAC.02183-15. [Epub ahead of print]
[h=1]NOVEL POLYANIONS INHIBITING REPLICATION OF INFLUENZA VIRUSES.[/h] Ciejka J[SUP]1[/SUP], Milewska A[SUP]2[/SUP], Wytrwal M[SUP]3[/SUP], Wojarski J[SUP]4[/SUP], Golda A[SUP]2[/SUP], Ochman M[SUP]4[/SUP], Nowakowska M[SUP]1[/SUP], Szczubialka K[SUP]5[/SUP], Pyrc K[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NSPAHs were found to be non-toxic and very well soluble in water, in contrast to gel-forming and thus generally poorly soluble carrageenans. In vitro and ex vivo studies using susceptible cells (Madin-Darby canine kidney epithelial cells and fully differentiated human airway epithelial cultures) demonstrated the antiviral effectiveness of NSPAHs. The activity of NSPAHs was proportional to the molecular weight of the chain and the degree of substitution of amino groups with sulfonate groups. Mechanistic studies showed that the NSPAHs and carrageenans inhibit influenza A and B viruses assembly in the cell.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26729490 [PubMed - as supplied by publisher]
[h=1]NOVEL POLYANIONS INHIBITING REPLICATION OF INFLUENZA VIRUSES.[/h] Ciejka J[SUP]1[/SUP], Milewska A[SUP]2[/SUP], Wytrwal M[SUP]3[/SUP], Wojarski J[SUP]4[/SUP], Golda A[SUP]2[/SUP], Ochman M[SUP]4[/SUP], Nowakowska M[SUP]1[/SUP], Szczubialka K[SUP]5[/SUP], Pyrc K[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Novel sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) and N-sulfonated chitosan (NSCH) have been synthesized and their activity against influenza A and B viruses has been studied and compared with that of a series of carrageenans, marine polysaccharides of well-documented anti-influenza activity. NSPAHs were found to be non-toxic and very well soluble in water, in contrast to gel-forming and thus generally poorly soluble carrageenans. In vitro and ex vivo studies using susceptible cells (Madin-Darby canine kidney epithelial cells and fully differentiated human airway epithelial cultures) demonstrated the antiviral effectiveness of NSPAHs. The activity of NSPAHs was proportional to the molecular weight of the chain and the degree of substitution of amino groups with sulfonate groups. Mechanistic studies showed that the NSPAHs and carrageenans inhibit influenza A and B viruses assembly in the cell.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26729490 [PubMed - as supplied by publisher]