Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China

[tetano]

J Clin Virol. 2014 Oct 28;61(4):529-534. doi: 10.1016/j.jcv.2014.10.014. [Epub ahead of print]
Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China.
Qiao C1, Liu L1, Yang H1, Chen Y1, Xu H1, Chen H2.
Author information
Abstract
BACKGROUND:

The pandemic A/H1N1 influenza viruses emerged in both Mexico and the United States in March 2009, and were transmitted efficiently in the human population. Transmissions of the pandemic 2009/H1N1 virus from humans to poultry and other species of mammals were reported from several continents during the course of the 2009 H1N1 pandemic. Reassortant H1N1, H1N2, and H3N2 viruses containing genes of the pandemic 2009/H1N1 viruses appeared in pigs in some countries.
STUDY DESIGN:

In winter of 2012, a total of 2600 nasal swabs were collected from healthy pigs in slaughterhouses located throughout 10 provinces in China. The isolated viruses were subjected to genetic and antigenic analysis. Two novel triple-reassortant H1N2 influenza viruses were isolated from swine in China in 2012, with the HA gene derived from Eurasian avian-like swine H1N1, the NA gene from North American swine H1N2, and the six internal genes from the pandemic 2009/H1N1 viruses. The two viruses had similar antigenic features and some significant changes in antigenic characteristics emerged when compared to the previously identified isolates.
CONCLUSION:

We inferred that the novel reassortant viruses in China may have arisen from the accumulation of the three types of influenza viruses, which further indicates that swine herds serve as "mixing vessels" for influenza viruses. Influenza virus reassortment is an ongoing process, and our findings highlight the urgent need for continued influenza surveillance among swine herds.

Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:

Genetic analysis; H1N2; Novel reassortant; Swine influenza virus

PMID:
25467861
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25467861

 

[AlaskaDenise]

Re: Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China

If this H1N2 strain were to adapt intact to humans, would it have an increased virulence due to characterisitics it picked up from H3N2, or simply from being novel? Once again we see major parts from 3 continents - and we can ponder just how they managed to combine.

Looking at the 92 sequences of human H1N2 since 2000, it looks like major changes occured about 2012.

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