tetano
Editor, Senior Moderator
NPJ Parkinsons Dis
. 2020 Aug 20;6:18.
doi: 10.1038/s41531-020-00123-0. eCollection 2020.
COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside
David Sulzer[SUP] 1 [/SUP], Angelo Antonini[SUP] 2 [/SUP], Valentina Leta[SUP] 3 4 [/SUP], Anna Nordvig[SUP] 5 [/SUP], Richard J Smeyne[SUP] 6 [/SUP], James E Goldman[SUP] 7 [/SUP], Osama Al-Dalahmah[SUP] 7 [/SUP], Luigi Zecca[SUP] 8 [/SUP], Alessandro Sette[SUP] 9 10 [/SUP], Luigi Bubacco[SUP] 11 [/SUP], Olimpia Meucci[SUP] 12 13 14 [/SUP], Elena Moro[SUP] 15 16 17 [/SUP], Ashley S Harms[SUP] 18 [/SUP], Yaqian Xu[SUP] 19 [/SUP], Stanley Fahn[SUP] 5 [/SUP], K Ray Chaudhuri[SUP] 3 4 [/SUP]
Affiliations
Abstract
This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson's disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson's patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson's disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia.
Keywords: Translational research.
. 2020 Aug 20;6:18.
doi: 10.1038/s41531-020-00123-0. eCollection 2020.
COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside
David Sulzer[SUP] 1 [/SUP], Angelo Antonini[SUP] 2 [/SUP], Valentina Leta[SUP] 3 4 [/SUP], Anna Nordvig[SUP] 5 [/SUP], Richard J Smeyne[SUP] 6 [/SUP], James E Goldman[SUP] 7 [/SUP], Osama Al-Dalahmah[SUP] 7 [/SUP], Luigi Zecca[SUP] 8 [/SUP], Alessandro Sette[SUP] 9 10 [/SUP], Luigi Bubacco[SUP] 11 [/SUP], Olimpia Meucci[SUP] 12 13 14 [/SUP], Elena Moro[SUP] 15 16 17 [/SUP], Ashley S Harms[SUP] 18 [/SUP], Yaqian Xu[SUP] 19 [/SUP], Stanley Fahn[SUP] 5 [/SUP], K Ray Chaudhuri[SUP] 3 4 [/SUP]
Affiliations
- PMID: 32885037
- PMCID: PMC7441399
- DOI: 10.1038/s41531-020-00123-0
Abstract
This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson's disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson's patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson's disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia.
Keywords: Translational research.