tetano
Editor, Senior Moderator
NPJ Vaccines
. 2024 Jul 22;9(1):132.
doi: 10.1038/s41541-024-00924-x. A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses
Syamala Rani Thimmiraju[SUP] 1 2 [/SUP], Rakesh Adhikari[SUP] 1 2 [/SUP], JeAnna R Redd[SUP] 1 2 [/SUP], Maria Jose Villar[SUP] 1 2 [/SUP], Jungsoon Lee[SUP] 1 2 [/SUP], Zhuyun Liu[SUP] 1 2 [/SUP], Yi-Lin Chen[SUP] 1 2 [/SUP], Suman Sharma[SUP] 3 [/SUP], Amandeep Kaur[SUP] 1 2 [/SUP], Nestor L Uzcategui[SUP] 1 2 [/SUP], Shannon E Ronca[SUP] 1 2 3 [/SUP], Wen-Hsiang Chen[SUP] 1 2 [/SUP], Jason T Kimata[SUP] 3 [/SUP], Bin Zhan[SUP] 1 2 [/SUP], Ulrich Strych[SUP] 1 2 [/SUP], Maria Elena Bottazzi[SUP] 1 2 4 5 [/SUP], Peter J Hotez[SUP] 1 2 4 5 [/SUP], Jeroen Pollet[SUP] 6 7 8 [/SUP]
Affiliations
The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.
. 2024 Jul 22;9(1):132.
doi: 10.1038/s41541-024-00924-x. A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses
Syamala Rani Thimmiraju[SUP] 1 2 [/SUP], Rakesh Adhikari[SUP] 1 2 [/SUP], JeAnna R Redd[SUP] 1 2 [/SUP], Maria Jose Villar[SUP] 1 2 [/SUP], Jungsoon Lee[SUP] 1 2 [/SUP], Zhuyun Liu[SUP] 1 2 [/SUP], Yi-Lin Chen[SUP] 1 2 [/SUP], Suman Sharma[SUP] 3 [/SUP], Amandeep Kaur[SUP] 1 2 [/SUP], Nestor L Uzcategui[SUP] 1 2 [/SUP], Shannon E Ronca[SUP] 1 2 3 [/SUP], Wen-Hsiang Chen[SUP] 1 2 [/SUP], Jason T Kimata[SUP] 3 [/SUP], Bin Zhan[SUP] 1 2 [/SUP], Ulrich Strych[SUP] 1 2 [/SUP], Maria Elena Bottazzi[SUP] 1 2 4 5 [/SUP], Peter J Hotez[SUP] 1 2 4 5 [/SUP], Jeroen Pollet[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 39034332
- DOI: 10.1038/s41541-024-00924-x
The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.