tetano
Editor, Senior Moderator
NPJ Vaccines
. 2025 Jan 17;10(1):11.
doi: 10.1038/s41541-024-01057-x. Antibody responses against influenza A decline with successive years of annual influenza vaccination
Sheena G Sullivan[SUP] 1 2 3 4 [/SUP], Arseniy Khvorov[SUP] 5 6 [/SUP], Louise Carolan[SUP] 5 [/SUP], Leslie Dowson[SUP] 6 [/SUP], A Jessica Hadiprodjo[SUP] 5 6 [/SUP], Stephany Sánchez-Ovando[SUP] 5 6 [/SUP], Yi Liu[SUP] 5 6 [/SUP], Vivian K Y Leung[SUP] 6 7 8 [/SUP], David Hodgson[SUP] 9 [/SUP], Christopher C Blyth[SUP] 10 11 12 13 [/SUP], Marion Macnish[SUP] 10 [/SUP], Allen C Cheng[SUP] 14 15 [/SUP], Michelle Haugenauer[SUP] 15 [/SUP], Julia Clark[SUP] 16 17 [/SUP], Sonia Dougherty[SUP] 16 [/SUP], Kristine Macartney[SUP] 18 [/SUP], Archana Koirala[SUP] 18 [/SUP], Ameneh Khatami[SUP] 18 19 [/SUP], Ajay Jadhav[SUP] 18 [/SUP], Helen Marshall[SUP] 20 21 [/SUP], Kathryn E Riley[SUP] 20 [/SUP], Peter A B Wark[SUP] 22 23 [/SUP], Catherine Delahunty[SUP] 22 23 [/SUP], Kanta Subbarao[SUP] 5 24 [/SUP], Adam J Kucharski[SUP] 9 [/SUP], Annette Fox[SUP] 5 6 [/SUP]
Affiliations
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.
. 2025 Jan 17;10(1):11.
doi: 10.1038/s41541-024-01057-x. Antibody responses against influenza A decline with successive years of annual influenza vaccination
Sheena G Sullivan[SUP] 1 2 3 4 [/SUP], Arseniy Khvorov[SUP] 5 6 [/SUP], Louise Carolan[SUP] 5 [/SUP], Leslie Dowson[SUP] 6 [/SUP], A Jessica Hadiprodjo[SUP] 5 6 [/SUP], Stephany Sánchez-Ovando[SUP] 5 6 [/SUP], Yi Liu[SUP] 5 6 [/SUP], Vivian K Y Leung[SUP] 6 7 8 [/SUP], David Hodgson[SUP] 9 [/SUP], Christopher C Blyth[SUP] 10 11 12 13 [/SUP], Marion Macnish[SUP] 10 [/SUP], Allen C Cheng[SUP] 14 15 [/SUP], Michelle Haugenauer[SUP] 15 [/SUP], Julia Clark[SUP] 16 17 [/SUP], Sonia Dougherty[SUP] 16 [/SUP], Kristine Macartney[SUP] 18 [/SUP], Archana Koirala[SUP] 18 [/SUP], Ameneh Khatami[SUP] 18 19 [/SUP], Ajay Jadhav[SUP] 18 [/SUP], Helen Marshall[SUP] 20 21 [/SUP], Kathryn E Riley[SUP] 20 [/SUP], Peter A B Wark[SUP] 22 23 [/SUP], Catherine Delahunty[SUP] 22 23 [/SUP], Kanta Subbarao[SUP] 5 24 [/SUP], Adam J Kucharski[SUP] 9 [/SUP], Annette Fox[SUP] 5 6 [/SUP]
Affiliations
- PMID: 39820465
- DOI: 10.1038/s41541-024-01057-x
Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.