tetano
Editor, Senior Moderator
NPJ Vaccines
. 2023 Feb 20;8(1):21.
doi: 10.1038/s41541-023-00621-1.
Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children
Tim K Tsang[SUP] 1 2 [/SUP], Can Wang[SUP] 3 [/SUP], Nicole N Y Tsang[SUP] 3 [/SUP], Vicky J Fang[SUP] 3 [/SUP], Ranawaka A P M Perera[SUP] 3 [/SUP], J S Malik Peiris[SUP] 3 4 [/SUP], Gabriel M Leung[SUP] 3 5 [/SUP], Benjamin J Cowling[SUP] 3 5 [/SUP], Dennis K M Ip[SUP] 6 [/SUP]
Affiliations
Abstract
In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers ≥40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers ≥40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients.
. 2023 Feb 20;8(1):21.
doi: 10.1038/s41541-023-00621-1.
Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children
Tim K Tsang[SUP] 1 2 [/SUP], Can Wang[SUP] 3 [/SUP], Nicole N Y Tsang[SUP] 3 [/SUP], Vicky J Fang[SUP] 3 [/SUP], Ranawaka A P M Perera[SUP] 3 [/SUP], J S Malik Peiris[SUP] 3 4 [/SUP], Gabriel M Leung[SUP] 3 5 [/SUP], Benjamin J Cowling[SUP] 3 5 [/SUP], Dennis K M Ip[SUP] 6 [/SUP]
Affiliations
- PMID: 36804941
- PMCID: PMC9940051
- DOI: 10.1038/s41541-023-00621-1
Abstract
In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers ≥40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers ≥40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients.