tetano
Editor, Senior Moderator
Obes Med
. 2020 Sep;19:100259.
doi: 10.1016/j.obmed.2020.100259. Epub 2020 May 26.
Potential Pathophysiological Mechanisms Leading to Increased COVID-19 Susceptibility and Severity in Obesity
Andrej Belančić[SUP] 1 [/SUP], Andrea Kresović[SUP] 2 [/SUP], Valentino Rački[SUP] 3 [/SUP]
Affiliations
Abstract
As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
Keywords: Angiotensin converting enzyme 2; Coronavirus; Cytokines; Obesity; Vitamin D.
. 2020 Sep;19:100259.
doi: 10.1016/j.obmed.2020.100259. Epub 2020 May 26.
Potential Pathophysiological Mechanisms Leading to Increased COVID-19 Susceptibility and Severity in Obesity
Andrej Belančić[SUP] 1 [/SUP], Andrea Kresović[SUP] 2 [/SUP], Valentino Rački[SUP] 3 [/SUP]
Affiliations
- PMID: 32501427
- PMCID: PMC7255205
- DOI: 10.1016/j.obmed.2020.100259
Abstract
As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
Keywords: Angiotensin converting enzyme 2; Coronavirus; Cytokines; Obesity; Vitamin D.