tetano
Editor, Senior Moderator
Obes Med
. 2020 Sep 24;100303.
doi: 10.1016/j.obmed.2020.100303. Online ahead of print.
Single cell sequencing unraveling genetic basis of shared immunologic switch between Severe COVID19 and Obesity
Antoine Fakhry AbdelMassih[SUP] 1 2 [/SUP], Jianping Ye[SUP] 3 [/SUP], Aya Kamel[SUP] 4 [/SUP], Fady Mishriky[SUP] 4 [/SUP], Habiba-Allah Ismail[SUP] 4 [/SUP], Layla El Qadi[SUP] 4 [/SUP], Lauris Malak[SUP] 1 [/SUP], Maram Mohamed[SUP] 4 [/SUP], Mariem Arsanyous[SUP] 4 [/SUP], Maysa Hazem[SUP] 4 [/SUP], Miral El-Husseiny[SUP] 4 [/SUP], Mirette Ashraf[SUP] 4 [/SUP], Nada Hafez[SUP] 4 [/SUP], Nada AlShehry[SUP] 4 [/SUP], Nadine El-Husseiny[SUP] 5 6 [/SUP], Nora AbdelRaouf[SUP] 4 [/SUP], Noura Shebl[SUP] 4 [/SUP], Nouran Hafez[SUP] 4 [/SUP], Nourhan Youssef[SUP] 4 [/SUP], Peter Afdal[SUP] 4 [/SUP], Rafeef Hozaien[SUP] 4 [/SUP], Rahma Menshawey[SUP] 4 [/SUP], Rana Saeed[SUP] 4 [/SUP], Reem Yasser[SUP] 7 [/SUP], Shereen Hesham[SUP] 8 [/SUP], Wesam Zakarriah[SUP] 9 [/SUP], Shahenda Khattab[SUP] 10 [/SUP], Yasmine Elammary[SUP] 11 12 [/SUP], Raghda Fouda[SUP] 11 12 13 [/SUP]
Affiliations
Abstract
COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones.. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously. It has also forged a connection between the genetic and immune cellular mechanisms underlying COVID infection and the inflammatory state of obese patients, offering a more accurate explanation as to why obese patients are at increased risk of poor COVID outcomes. These commonalities encompass macrophage phenotype switching, genetic expression switching, and overexpression of the pro-inflammatory cytokines, depletion of the regulatory cytokines, in situ T cell proliferation, and T cell exhaustion. These findings demonstrate the necessity of single cell sequencing as a rapid means to identify and treat those who are most likely to need hospital admission and intensive care, in the hopes of precision medicine. Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one.
Keywords: COVID-19; Obesity; Single Cell Sequencing; beneficial inflammation; deleterious inflammation; immunologic switch; shared immunogenetics.
. 2020 Sep 24;100303.
doi: 10.1016/j.obmed.2020.100303. Online ahead of print.
Single cell sequencing unraveling genetic basis of shared immunologic switch between Severe COVID19 and Obesity
Antoine Fakhry AbdelMassih[SUP] 1 2 [/SUP], Jianping Ye[SUP] 3 [/SUP], Aya Kamel[SUP] 4 [/SUP], Fady Mishriky[SUP] 4 [/SUP], Habiba-Allah Ismail[SUP] 4 [/SUP], Layla El Qadi[SUP] 4 [/SUP], Lauris Malak[SUP] 1 [/SUP], Maram Mohamed[SUP] 4 [/SUP], Mariem Arsanyous[SUP] 4 [/SUP], Maysa Hazem[SUP] 4 [/SUP], Miral El-Husseiny[SUP] 4 [/SUP], Mirette Ashraf[SUP] 4 [/SUP], Nada Hafez[SUP] 4 [/SUP], Nada AlShehry[SUP] 4 [/SUP], Nadine El-Husseiny[SUP] 5 6 [/SUP], Nora AbdelRaouf[SUP] 4 [/SUP], Noura Shebl[SUP] 4 [/SUP], Nouran Hafez[SUP] 4 [/SUP], Nourhan Youssef[SUP] 4 [/SUP], Peter Afdal[SUP] 4 [/SUP], Rafeef Hozaien[SUP] 4 [/SUP], Rahma Menshawey[SUP] 4 [/SUP], Rana Saeed[SUP] 4 [/SUP], Reem Yasser[SUP] 7 [/SUP], Shereen Hesham[SUP] 8 [/SUP], Wesam Zakarriah[SUP] 9 [/SUP], Shahenda Khattab[SUP] 10 [/SUP], Yasmine Elammary[SUP] 11 12 [/SUP], Raghda Fouda[SUP] 11 12 13 [/SUP]
Affiliations
- PMID: 32995660
- PMCID: PMC7513689
- DOI: 10.1016/j.obmed.2020.100303
Abstract
COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones.. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously. It has also forged a connection between the genetic and immune cellular mechanisms underlying COVID infection and the inflammatory state of obese patients, offering a more accurate explanation as to why obese patients are at increased risk of poor COVID outcomes. These commonalities encompass macrophage phenotype switching, genetic expression switching, and overexpression of the pro-inflammatory cytokines, depletion of the regulatory cytokines, in situ T cell proliferation, and T cell exhaustion. These findings demonstrate the necessity of single cell sequencing as a rapid means to identify and treat those who are most likely to need hospital admission and intensive care, in the hopes of precision medicine. Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one.
Keywords: COVID-19; Obesity; Single Cell Sequencing; beneficial inflammation; deleterious inflammation; immunologic switch; shared immunogenetics.