tetano
Editor, Senior Moderator
Pulm Pharmacol Ther. 2012 May 24. [Epub ahead of print]
Obesity and respiratory infections: Does excess adiposity weigh down host defense?
Mancuso P.
Source
Department of Environmental Health Sciences and the Graduate Program in Immunology, 109 S. Observatory Street, School of Public Health, University of Michigan, 6627 SPH1A, Ann Arbor, MI 48109-2029, USA.
Abstract
The number of overweight and obese individuals has dramatically increased in the US and other developed nations during the past 30 years. While type II diabetes and cardiovascular disease are well recognized co-morbid conditions associated with obesity, recent reports have demonstrated a greater severity of illness in obese patients due to influenza during the 2009 H1N1 pandemic. Consistent with these reports, diet-induced obesity has been shown to impair anti-viral host defense in murine models of influenza infection. However, the impact of obesity on the risk of community-acquired and nosocomial pneumonia in human patients is not clear. Relatively few studies have evaluated the influence of diet-induced obesity in murine models of bacterial infections of the respiratory tract. Obese leptin deficient humans and leptin and leptin-receptor deficient mice exhibit greater susceptibility to respiratory infections suggesting a requirement for leptin in the pulmonary innate and adaptive immune response to infection. In contrast to these studies, we have observed that obese leptin receptor signaling mutant mice are resistant to pneumococcal pneumonia highlighting the complex interaction between leptin receptor signaling and immune function. Given the increased prevalence of obesity and poor responsiveness of obese individuals to vaccination against influenza, the development of novel immunization strategies for this population is warranted. Additional clinical and animal studies are needed to clarify the relationship between increased adiposity and susceptibility to community-acquired and nosocomial pneumonia.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22634305
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22634305
Obesity and respiratory infections: Does excess adiposity weigh down host defense?
Mancuso P.
Source
Department of Environmental Health Sciences and the Graduate Program in Immunology, 109 S. Observatory Street, School of Public Health, University of Michigan, 6627 SPH1A, Ann Arbor, MI 48109-2029, USA.
Abstract
The number of overweight and obese individuals has dramatically increased in the US and other developed nations during the past 30 years. While type II diabetes and cardiovascular disease are well recognized co-morbid conditions associated with obesity, recent reports have demonstrated a greater severity of illness in obese patients due to influenza during the 2009 H1N1 pandemic. Consistent with these reports, diet-induced obesity has been shown to impair anti-viral host defense in murine models of influenza infection. However, the impact of obesity on the risk of community-acquired and nosocomial pneumonia in human patients is not clear. Relatively few studies have evaluated the influence of diet-induced obesity in murine models of bacterial infections of the respiratory tract. Obese leptin deficient humans and leptin and leptin-receptor deficient mice exhibit greater susceptibility to respiratory infections suggesting a requirement for leptin in the pulmonary innate and adaptive immune response to infection. In contrast to these studies, we have observed that obese leptin receptor signaling mutant mice are resistant to pneumococcal pneumonia highlighting the complex interaction between leptin receptor signaling and immune function. Given the increased prevalence of obesity and poor responsiveness of obese individuals to vaccination against influenza, the development of novel immunization strategies for this population is warranted. Additional clinical and animal studies are needed to clarify the relationship between increased adiposity and susceptibility to community-acquired and nosocomial pneumonia.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22634305
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22634305