tetano
Editor, Senior Moderator
Obesity (Silver Spring)
. 2020 Jul 17.
doi: 10.1002/oby.22971. Online ahead of print.
Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars-COV-2
Yang Yang[SUP] 1 [/SUP], Lin Ding[SUP] 1 [/SUP], Xianlun Zou[SUP] 1 [/SUP], Yaqi Shen[SUP] 1 [/SUP], Daoyu Hu[SUP] 1 [/SUP], Xuemei Hu[SUP] 1 [/SUP], Zhen Li[SUP] 1 [/SUP], Ihab R Kamel[SUP] 2 [/SUP]
Affiliations
Abstract
Objects: To assess the association between adipose tissue distribution and severity of clinical course in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: For this retrospective study, 143 hospitalized patients with confirmed coronavirus disease 2019(COVID-19) who underwent un-enhanced abdominal computed tomography (CT) scan between January 1[SUP]th[/SUP] , 2020 and March 30[SUP]th[/SUP] , 2020 were included. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the severity of COVID-19 infection.
Results: There were 45 patients who were identified as critically ill. High visceral to subcutaneous adipose tissue area ratio (VSR, called visceral adiposity) (OR: 2.47, 95CI: 1.05 to 5.98, p=0.040) and low mean attenuation of skeletal muscle (SMD, called high intramuscular fat [IMF] deposition) (OR: 11.90, 95CI: 4.50 to 36.14, p<0.001) were independent risk factors for critical illness. Furthermore, visceral adiposity or high IMF deposition increased the risk of mechanical ventilation (p=0.013, p<0.001; respectively). High IMF deposition increased the risk of death (p=0.012).
Conclusion: COVID-19 patients with visceral adiposity or high IMF deposition have higher risk for critical illness. Hence, patients with abdominal obesity should be monitored more carefully when hospitalized.
Keywords: Body Composition; Computed Tomography; Critical Care; Pulmonary Disease; Visceral Obesity.
. 2020 Jul 17.
doi: 10.1002/oby.22971. Online ahead of print.
Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars-COV-2
Yang Yang[SUP] 1 [/SUP], Lin Ding[SUP] 1 [/SUP], Xianlun Zou[SUP] 1 [/SUP], Yaqi Shen[SUP] 1 [/SUP], Daoyu Hu[SUP] 1 [/SUP], Xuemei Hu[SUP] 1 [/SUP], Zhen Li[SUP] 1 [/SUP], Ihab R Kamel[SUP] 2 [/SUP]
Affiliations
- PMID: 32677752
- DOI: 10.1002/oby.22971
Abstract
Objects: To assess the association between adipose tissue distribution and severity of clinical course in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: For this retrospective study, 143 hospitalized patients with confirmed coronavirus disease 2019(COVID-19) who underwent un-enhanced abdominal computed tomography (CT) scan between January 1[SUP]th[/SUP] , 2020 and March 30[SUP]th[/SUP] , 2020 were included. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the severity of COVID-19 infection.
Results: There were 45 patients who were identified as critically ill. High visceral to subcutaneous adipose tissue area ratio (VSR, called visceral adiposity) (OR: 2.47, 95CI: 1.05 to 5.98, p=0.040) and low mean attenuation of skeletal muscle (SMD, called high intramuscular fat [IMF] deposition) (OR: 11.90, 95CI: 4.50 to 36.14, p<0.001) were independent risk factors for critical illness. Furthermore, visceral adiposity or high IMF deposition increased the risk of mechanical ventilation (p=0.013, p<0.001; respectively). High IMF deposition increased the risk of death (p=0.012).
Conclusion: COVID-19 patients with visceral adiposity or high IMF deposition have higher risk for critical illness. Hence, patients with abdominal obesity should be monitored more carefully when hospitalized.
Keywords: Body Composition; Computed Tomography; Critical Care; Pulmonary Disease; Visceral Obesity.