tetano
Editor, Senior Moderator
Ocul Immunol Inflamm
. 2023 Jun 22;1-9.
doi: 10.1080/09273948.2023.2219312. Online ahead of print. The Impact of Severe COVID-19 on Corneal Endothelial Cells-Analysis of the In Vivo Noncontact Specular Microscopy
Nurettin Bayram[SUP] 1 2 [/SUP], Cemal Ozsaygılı[SUP] 1 [/SUP], Medine Gundogan[SUP] 1 [/SUP], Sefa Unal[SUP] 1 [/SUP], Fatma Bagci[SUP] 2 [/SUP], Emine Pangal[SUP] 1 [/SUP], I Sa Yuvacı[SUP] 3 [/SUP]
Affiliations
Purpose: This study aimed to investigate the effects of severe COVID-19 infection on the corneal endothelium via in vivo specular microscopy.
Methods: This was an observational, prospective, and controlled study including 56 eyes of 56 severe COVID-19 patients, compared to after-recovery and 56 eyes of 56 age- and gender-matched healthy controls.
Results: Endothelial cell density was lower in the active disease period compared to healthy controls (p = .001) and decreased even more after recovery (p < .0001). After recovery, the average cell area and coefficient of variation were higher compared to the active disease period (p < .0001 and p = .008, respectively) and the healthy controls (for both, p < .0001), whereas hexagonality was lower (p < .0001). Central corneal thickness increased in the active disease period compared to after recovery (p < .0001) and healthy controls (p = .002).
Conclusions: These results may be due to direct host-virus interaction or linked to immune dysregulation, subclinical corneal endotheliitis, or still yet a viral-mediated inflammation.
Keywords: Cornea; coronavirus disease 2019; endothelium; optical biometry; specular microscopy.
. 2023 Jun 22;1-9.
doi: 10.1080/09273948.2023.2219312. Online ahead of print. The Impact of Severe COVID-19 on Corneal Endothelial Cells-Analysis of the In Vivo Noncontact Specular Microscopy
Nurettin Bayram[SUP] 1 2 [/SUP], Cemal Ozsaygılı[SUP] 1 [/SUP], Medine Gundogan[SUP] 1 [/SUP], Sefa Unal[SUP] 1 [/SUP], Fatma Bagci[SUP] 2 [/SUP], Emine Pangal[SUP] 1 [/SUP], I Sa Yuvacı[SUP] 3 [/SUP]
Affiliations
- PMID: 37348068
- DOI: 10.1080/09273948.2023.2219312
Purpose: This study aimed to investigate the effects of severe COVID-19 infection on the corneal endothelium via in vivo specular microscopy.
Methods: This was an observational, prospective, and controlled study including 56 eyes of 56 severe COVID-19 patients, compared to after-recovery and 56 eyes of 56 age- and gender-matched healthy controls.
Results: Endothelial cell density was lower in the active disease period compared to healthy controls (p = .001) and decreased even more after recovery (p < .0001). After recovery, the average cell area and coefficient of variation were higher compared to the active disease period (p < .0001 and p = .008, respectively) and the healthy controls (for both, p < .0001), whereas hexagonality was lower (p < .0001). Central corneal thickness increased in the active disease period compared to after recovery (p < .0001) and healthy controls (p = .002).
Conclusions: These results may be due to direct host-virus interaction or linked to immune dysregulation, subclinical corneal endotheliitis, or still yet a viral-mediated inflammation.
Keywords: Cornea; coronavirus disease 2019; endothelium; optical biometry; specular microscopy.