tetano
Editor, Senior Moderator
J Infect. 2015 Nov 26. pii: S0163-4453(15)00365-5. doi: 10.1016/j.jinf.2015.10.013. [Epub ahead of print]
[h=1]Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: a prospective seroepidemiology study.[/h] To KK[SUP]1[/SUP], Hung IF[SUP]2[/SUP], Lui YM[SUP]3[/SUP], Mok FK[SUP]3[/SUP], Chan AS[SUP]3[/SUP], Li PT[SUP]3[/SUP], Wong TL[SUP]3[/SUP], Ho DT[SUP]3[/SUP], Chan JF[SUP]1[/SUP], Chan KH[SUP]1[/SUP], Yuen KY[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Stringent measures have been implemented in Hong Kong to prevent human infections due to avian influenza viruses (AIVs). Here, we report the seroprevalence of AIVs among high risk population.
[h=4]METHODS:[/h] In this prospective study, blood samples were collected in October and November 2013 and in July 2014 from workers at live poultry market (LPM) and pig/cattle slaughterhouse (SH) in Hong Kong. Serum antibody titers against A(H5N1), A(H7N9) and A(H9N2) were determined.
[h=4]RESULTS:[/h] When an hemagglutination inhibition (HI) titer of 40 was used as the cutoff, the A(H5N1) seropositive rate among LPM workers increased from 0% in 2013 to 37.8% in 2014 (P<0.001) and the A(H9N2) seropositive rate increased from 10% to 55.6% (P<0.001). There was no significant increase in A(H7N9) seropositive rate for LPM workers irrespective of cutoff titer. For SH workers, there was no significant increase in HI titer for any AIVs. Significantly more LPM workers had a ≥4-fold increase in A(H5N1) HI titer from 2013 to 2014 than SH workers (60% vs 8.3%, P=0.020).
[h=4]CONCLUSIONS:[/h] There was a significant increase of serum A(H5N1) and A(H9N2) HI titers among Hong Kong LPM workers between 2013 and 2014, suggesting the occurrence of subclinical AIV infections in this population.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] H5N1; H7N9; H9N2; Hong Kong; avian influenza; epidemiology; seroprevalence
PMID: 26632329 [PubMed - as supplied by publisher]
[h=1]Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: a prospective seroepidemiology study.[/h] To KK[SUP]1[/SUP], Hung IF[SUP]2[/SUP], Lui YM[SUP]3[/SUP], Mok FK[SUP]3[/SUP], Chan AS[SUP]3[/SUP], Li PT[SUP]3[/SUP], Wong TL[SUP]3[/SUP], Ho DT[SUP]3[/SUP], Chan JF[SUP]1[/SUP], Chan KH[SUP]1[/SUP], Yuen KY[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVES:[/h] Stringent measures have been implemented in Hong Kong to prevent human infections due to avian influenza viruses (AIVs). Here, we report the seroprevalence of AIVs among high risk population.
[h=4]METHODS:[/h] In this prospective study, blood samples were collected in October and November 2013 and in July 2014 from workers at live poultry market (LPM) and pig/cattle slaughterhouse (SH) in Hong Kong. Serum antibody titers against A(H5N1), A(H7N9) and A(H9N2) were determined.
[h=4]RESULTS:[/h] When an hemagglutination inhibition (HI) titer of 40 was used as the cutoff, the A(H5N1) seropositive rate among LPM workers increased from 0% in 2013 to 37.8% in 2014 (P<0.001) and the A(H9N2) seropositive rate increased from 10% to 55.6% (P<0.001). There was no significant increase in A(H7N9) seropositive rate for LPM workers irrespective of cutoff titer. For SH workers, there was no significant increase in HI titer for any AIVs. Significantly more LPM workers had a ≥4-fold increase in A(H5N1) HI titer from 2013 to 2014 than SH workers (60% vs 8.3%, P=0.020).
[h=4]CONCLUSIONS:[/h] There was a significant increase of serum A(H5N1) and A(H9N2) HI titers among Hong Kong LPM workers between 2013 and 2014, suggesting the occurrence of subclinical AIV infections in this population.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] H5N1; H7N9; H9N2; Hong Kong; avian influenza; epidemiology; seroprevalence
PMID: 26632329 [PubMed - as supplied by publisher]