tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Nov 6;9(1)
fab553.
doi: 10.1093/ofid/ofab553. eCollection 2022 Jan.
In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
Lidewij W Rümke[SUP] 1 [/SUP], Femke C Groenveld[SUP] 1 [/SUP], Yvonne M G van Os[SUP] 2 [/SUP], Patrique Praest[SUP] 1 [/SUP], Anniek A N Tanja[SUP] 1 [/SUP], Dorien T C M de Jong[SUP] 1 [/SUP], Jori Symons[SUP] 1 [/SUP], Rob Schuurman[SUP] 1 [/SUP], Tessa Reinders[SUP] 1 [/SUP], L Marije Hofstra[SUP] 1 [/SUP], Stefan Nierkens[SUP] 3 [/SUP], Steven F T Thijsen[SUP] 4 [/SUP], Michiel Heron[SUP] 4 [/SUP], Robert-Jan Lebbink[SUP] 1 [/SUP], Jeffrey M Beekman[SUP] 5 6 [/SUP], Monique Nijhuis[SUP] 1 [/SUP], Annemarie M J Wensing[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.
Keywords: COVID-19; SARS-CoV-2; immunity; postvaccination infection; vaccine breakthrough.
. 2021 Nov 6;9(1)
fab553.doi: 10.1093/ofid/ofab553. eCollection 2022 Jan.
In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center
Lidewij W Rümke[SUP] 1 [/SUP], Femke C Groenveld[SUP] 1 [/SUP], Yvonne M G van Os[SUP] 2 [/SUP], Patrique Praest[SUP] 1 [/SUP], Anniek A N Tanja[SUP] 1 [/SUP], Dorien T C M de Jong[SUP] 1 [/SUP], Jori Symons[SUP] 1 [/SUP], Rob Schuurman[SUP] 1 [/SUP], Tessa Reinders[SUP] 1 [/SUP], L Marije Hofstra[SUP] 1 [/SUP], Stefan Nierkens[SUP] 3 [/SUP], Steven F T Thijsen[SUP] 4 [/SUP], Michiel Heron[SUP] 4 [/SUP], Robert-Jan Lebbink[SUP] 1 [/SUP], Jeffrey M Beekman[SUP] 5 6 [/SUP], Monique Nijhuis[SUP] 1 [/SUP], Annemarie M J Wensing[SUP] 1 [/SUP]
Affiliations
- PMID: 34988250
- PMCID: PMC8714358
- DOI: 10.1093/ofid/ofab553
Abstract
Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination.
Keywords: COVID-19; SARS-CoV-2; immunity; postvaccination infection; vaccine breakthrough.