tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 May 23;10(7)
fad271.
doi: 10.1093/ofid/ofad271. eCollection 2023 Jul. A Prospective Study of Key Correlates for Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2
Elizabeth R Brown[SUP] 1 2 [/SUP], Meagan P O'Brien[SUP] 3 [/SUP], Brian Snow[SUP] 3 [/SUP], Flonza Isa[SUP] 3 [/SUP], Eduardo Forleo-Neto[SUP] 3 [/SUP], Kuo-Chen Chan[SUP] 3 [/SUP], Peijie Hou[SUP] 3 [/SUP], Myron S Cohen[SUP] 4 [/SUP], Gary Herman[SUP] 3 [/SUP], Ruanne V Barnabas[SUP] 5 [/SUP]
Affiliations
Background: Randomized controlled trials evaluated monoclonal antibodies for the treatment (Study 2067) and prevention (Study 2069) of coronavirus disease 2019 (COVID-19). Household contacts of the infected index case in Study 2067 were enrolled in Study 2069 and prospectively followed; these cohorts provided a unique opportunity to evaluate correlates of transmission, specifically viral load.
Methods: This post hoc analysis was designed to identify and evaluate correlates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, adjusting for potential confounding factors related to source SARS-CoV-2 viral load and risk of SARS-CoV-2 acquisition in this population. Correlates of transmission were evaluated in potential transmission pairs (any infected household member plus susceptible household contact).
Results: In total, 943 participants were included. In multivariable regression, 2 potential correlates were determined to have a statistically significant (P < .05) association with transmission risk. A 10-fold increase in viral load was associated with a 40% increase in odds of transmission; sharing a bedroom with the index participant was associated with a 199% increase in odds of transmission.
Conclusions: In this prospective, post hoc analysis that controlled for confounders, the 2 key correlates for transmission of SARS-CoV-2 within a household are sharing a bedroom and increased viral load, consistent with increased exposure to the infected individual.
Keywords: COVID-19; SARS-CoV-2; acquisition; household; transmission.
. 2023 May 23;10(7)
fad271.doi: 10.1093/ofid/ofad271. eCollection 2023 Jul. A Prospective Study of Key Correlates for Household Transmission of Severe Acute Respiratory Syndrome Coronavirus 2
Elizabeth R Brown[SUP] 1 2 [/SUP], Meagan P O'Brien[SUP] 3 [/SUP], Brian Snow[SUP] 3 [/SUP], Flonza Isa[SUP] 3 [/SUP], Eduardo Forleo-Neto[SUP] 3 [/SUP], Kuo-Chen Chan[SUP] 3 [/SUP], Peijie Hou[SUP] 3 [/SUP], Myron S Cohen[SUP] 4 [/SUP], Gary Herman[SUP] 3 [/SUP], Ruanne V Barnabas[SUP] 5 [/SUP]
Affiliations
- PMID: 37416758
- PMCID: PMC10319621
- DOI: 10.1093/ofid/ofad271
Background: Randomized controlled trials evaluated monoclonal antibodies for the treatment (Study 2067) and prevention (Study 2069) of coronavirus disease 2019 (COVID-19). Household contacts of the infected index case in Study 2067 were enrolled in Study 2069 and prospectively followed; these cohorts provided a unique opportunity to evaluate correlates of transmission, specifically viral load.
Methods: This post hoc analysis was designed to identify and evaluate correlates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, adjusting for potential confounding factors related to source SARS-CoV-2 viral load and risk of SARS-CoV-2 acquisition in this population. Correlates of transmission were evaluated in potential transmission pairs (any infected household member plus susceptible household contact).
Results: In total, 943 participants were included. In multivariable regression, 2 potential correlates were determined to have a statistically significant (P < .05) association with transmission risk. A 10-fold increase in viral load was associated with a 40% increase in odds of transmission; sharing a bedroom with the index participant was associated with a 199% increase in odds of transmission.
Conclusions: In this prospective, post hoc analysis that controlled for confounders, the 2 key correlates for transmission of SARS-CoV-2 within a household are sharing a bedroom and increased viral load, consistent with increased exposure to the infected individual.
Keywords: COVID-19; SARS-CoV-2; acquisition; household; transmission.