tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Mar 30;8(7)
fab143.
doi: 10.1093/ofid/ofab143. eCollection 2021 Jul.
CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
Andrew D Redd[SUP] 1 2 [/SUP], Alessandra Nardin[SUP] 3 [/SUP], Hassen Kared[SUP] 3 [/SUP], Evan M Bloch[SUP] 4 [/SUP], Andrew Pekosz[SUP] 5 [/SUP], Oliver Laeyendecker[SUP] 1 2 [/SUP], Brian Abel[SUP] 3 [/SUP], Michael Fehlings[SUP] 3 [/SUP], Thomas C Quinn[SUP] 1 2 [/SUP], Aaron A R Tobian[SUP] 4 [/SUP]
Affiliations
Abstract
This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.
Keywords: CD8+ T cell; COVID-19; SARS-CoV-2; convalescent patients.
. 2021 Mar 30;8(7)
fab143.doi: 10.1093/ofid/ofab143. eCollection 2021 Jul.
CD8+ T-Cell Responses in COVID-19 Convalescent Individuals Target Conserved Epitopes From Multiple Prominent SARS-CoV-2 Circulating Variants
Andrew D Redd[SUP] 1 2 [/SUP], Alessandra Nardin[SUP] 3 [/SUP], Hassen Kared[SUP] 3 [/SUP], Evan M Bloch[SUP] 4 [/SUP], Andrew Pekosz[SUP] 5 [/SUP], Oliver Laeyendecker[SUP] 1 2 [/SUP], Brian Abel[SUP] 3 [/SUP], Michael Fehlings[SUP] 3 [/SUP], Thomas C Quinn[SUP] 1 2 [/SUP], Aaron A R Tobian[SUP] 4 [/SUP]
Affiliations
- PMID: 34322559
- PMCID: PMC8083629
- DOI: 10.1093/ofid/ofab143
Abstract
This study examined whether CD8+ T-cell responses from coronavirus disease 2019 convalescent individuals (n = 30) potentially maintain recognition of the major severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (alpha, beta, gamma; n = 45 mutations assessed). Only 1 mutation found in Beta variant-spike overlapped with a previously identified epitope (1/52), suggesting that virtually all anti-SARS-CoV-2 CD8+ T-cell responses should recognize these newly described variants.
Keywords: CD8+ T cell; COVID-19; SARS-CoV-2; convalescent patients.