tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jun 4;8(7)
fab300.
doi: 10.1093/ofid/ofab300. eCollection 2021 Jul.
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
Ahmed M Moustafa[SUP] 1 2 [/SUP], Colleen Bianco[SUP] 1 [/SUP], Lidiya Denu[SUP] 1 [/SUP], Azad Ahmed[SUP] 3 [/SUP], Susan E Coffin[SUP] 1 [/SUP], Brandy Neide[SUP] 1 [/SUP], John Everett[SUP] 4 [/SUP], Shantan Reddy[SUP] 4 [/SUP], Emilie Rabut[SUP] 5 [/SUP], Jasmine Deseignora[SUP] 5 [/SUP], Michael D Feldman[SUP] 6 [/SUP], Kyle G Rodino[SUP] 6 [/SUP], Frederic Bushman[SUP] 4 [/SUP], Rebecca M Harris[SUP] 6 7 [/SUP], Josh Chang Mell[SUP] 3 [/SUP], Paul J Planet[SUP] 1 7 8 [/SUP]
Affiliations
Abstract
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
Keywords: B.1.1.7+E484K; convergent; escape mutation; vaccine; variant of concern.
. 2021 Jun 4;8(7)
fab300.doi: 10.1093/ofid/ofab300. eCollection 2021 Jul.
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
Ahmed M Moustafa[SUP] 1 2 [/SUP], Colleen Bianco[SUP] 1 [/SUP], Lidiya Denu[SUP] 1 [/SUP], Azad Ahmed[SUP] 3 [/SUP], Susan E Coffin[SUP] 1 [/SUP], Brandy Neide[SUP] 1 [/SUP], John Everett[SUP] 4 [/SUP], Shantan Reddy[SUP] 4 [/SUP], Emilie Rabut[SUP] 5 [/SUP], Jasmine Deseignora[SUP] 5 [/SUP], Michael D Feldman[SUP] 6 [/SUP], Kyle G Rodino[SUP] 6 [/SUP], Frederic Bushman[SUP] 4 [/SUP], Rebecca M Harris[SUP] 6 7 [/SUP], Josh Chang Mell[SUP] 3 [/SUP], Paul J Planet[SUP] 1 7 8 [/SUP]
Affiliations
- PMID: 34254040
- PMCID: PMC8244812
- DOI: 10.1093/ofid/ofab300
Abstract
We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
Keywords: B.1.1.7+E484K; convergent; escape mutation; vaccine; variant of concern.