tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 May 26;8(7)
fab274.
doi: 10.1093/ofid/ofab274. eCollection 2021 Jul.
First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
Udaya S Tantry[SUP] 1 [/SUP], Kevin P Bliden[SUP] 1 [/SUP], Alastair Cho[SUP] 1 [/SUP], Naval Walia[SUP] 1 [/SUP], Jeffrey R Dahlen[SUP] 2 [/SUP], Gordon Ens[SUP] 3 [/SUP], Malina Traianova[SUP] 4 [/SUP], Christophe Jerjian[SUP] 1 [/SUP], Abira Usman[SUP] 1 [/SUP], Paul A Gurbel[SUP] 1 [/SUP]
Affiliations
Abstract
Urine 11-dehydro-thromboxane B[SUB]2[/SUB] (u11-dh-TxB[SUB]2[/SUB]), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB[SUB]2[/SUB] and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.
Keywords: COVID-19; liver-type fatty acid binding protein; urinary 11-dehydro- thromboxane B2; urinary 8-hydroxy-2’-deoxyguanosine.
. 2021 May 26;8(7)
fab274.doi: 10.1093/ofid/ofab274. eCollection 2021 Jul.
First Experience Addressing the Prognostic Utility of Novel Urinary Biomarkers in Patients With COVID-19
Udaya S Tantry[SUP] 1 [/SUP], Kevin P Bliden[SUP] 1 [/SUP], Alastair Cho[SUP] 1 [/SUP], Naval Walia[SUP] 1 [/SUP], Jeffrey R Dahlen[SUP] 2 [/SUP], Gordon Ens[SUP] 3 [/SUP], Malina Traianova[SUP] 4 [/SUP], Christophe Jerjian[SUP] 1 [/SUP], Abira Usman[SUP] 1 [/SUP], Paul A Gurbel[SUP] 1 [/SUP]
Affiliations
- PMID: 34250193
- PMCID: PMC8194603
- DOI: 10.1093/ofid/ofab274
Abstract
Urine 11-dehydro-thromboxane B[SUB]2[/SUB] (u11-dh-TxB[SUB]2[/SUB]), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and liver-type fatty acid binding protein levels (L-FABP) at the time of hospitalization were higher in coronavirus disease 2019 (COVID-19) patients with adverse events vs without events. Higher u11-dh-TxB[SUB]2[/SUB] and L-FABP levels were associated with longer hospitalization, more thrombotic events, and greater mortality, providing evidence for potential utility as early prognostic biomarkers for COVID-19.
Keywords: COVID-19; liver-type fatty acid binding protein; urinary 11-dehydro- thromboxane B2; urinary 8-hydroxy-2’-deoxyguanosine.