tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jan 28;8(2)
fab029.
doi: 10.1093/ofid/ofab029. eCollection 2021 Feb.
HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City
Justin Laracy[SUP] 1 2 [/SUP], Jason Zucker[SUP] 3 [/SUP], Delivette Castor[SUP] 3 [/SUP], Donald J McMahon[SUP] 4 [/SUP], Tai Wei Guo[SUP] 5 [/SUP], Michael Yan[SUP] 6 [/SUP], Noga Shalev[SUP] 3 [/SUP], Matthew Scherer[SUP] 3 [/SUP], Peter Gordon[SUP] 3 [/SUP], Magdalena Sobieszczyk[SUP] 3 [/SUP], Michael T Yin[SUP] 3 [/SUP]
Affiliations
Abstract
Background: The clinical impact of coronavirus disease 2019 (COVID-19) among people with HIV (PWH) remains unclear. In this retrospective cohort study of COVID-19, we compared clinical outcomes and laboratory parameters among PWH and controls.
Methods: Sixty-eight PWH diagnosed with COVID-19 were matched 1:4 to patients without known HIV diagnosis, drawn from a study population of all patients who were diagnosed with COVID-19 at an academic urban hospital. The primary outcome was death/discharge to hospice within 30 days of hospital presentation.
Results: PWH were more likely to be admitted from the emergency department than patients without HIV (91% vs 71%; P = .001). We observed no statistically significant difference between admitted PWH and patients without HIV in terms of 30-day mortality rate (19% vs 13%, respectively) or mechanical ventilation rate (18% vs 20%, respectively). PWH had higher erythrocyte sedimentation rates than controls on admission but did not differ in other inflammatory marker levels or nasopharyngeal/oropharyngeal severe acute respiratory syndrome coronavirus 2 viral load estimated by reverse transcriptase polymerase chain reaction cycle thresholds.
Conclusions: HIV infection status was associated with a higher admission rate; however, among hospitalized patients, PWH did not differ from HIV-uninfected controls by rate of mechanical ventilation or death/discharge to hospice.
Keywords: COVID-19; HIV-1; SARS-CoV-2.
. 2021 Jan 28;8(2)
fab029.doi: 10.1093/ofid/ofab029. eCollection 2021 Feb.
HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City
Justin Laracy[SUP] 1 2 [/SUP], Jason Zucker[SUP] 3 [/SUP], Delivette Castor[SUP] 3 [/SUP], Donald J McMahon[SUP] 4 [/SUP], Tai Wei Guo[SUP] 5 [/SUP], Michael Yan[SUP] 6 [/SUP], Noga Shalev[SUP] 3 [/SUP], Matthew Scherer[SUP] 3 [/SUP], Peter Gordon[SUP] 3 [/SUP], Magdalena Sobieszczyk[SUP] 3 [/SUP], Michael T Yin[SUP] 3 [/SUP]
Affiliations
- PMID: 33604406
- PMCID: PMC7880266
- DOI: 10.1093/ofid/ofab029
Abstract
Background: The clinical impact of coronavirus disease 2019 (COVID-19) among people with HIV (PWH) remains unclear. In this retrospective cohort study of COVID-19, we compared clinical outcomes and laboratory parameters among PWH and controls.
Methods: Sixty-eight PWH diagnosed with COVID-19 were matched 1:4 to patients without known HIV diagnosis, drawn from a study population of all patients who were diagnosed with COVID-19 at an academic urban hospital. The primary outcome was death/discharge to hospice within 30 days of hospital presentation.
Results: PWH were more likely to be admitted from the emergency department than patients without HIV (91% vs 71%; P = .001). We observed no statistically significant difference between admitted PWH and patients without HIV in terms of 30-day mortality rate (19% vs 13%, respectively) or mechanical ventilation rate (18% vs 20%, respectively). PWH had higher erythrocyte sedimentation rates than controls on admission but did not differ in other inflammatory marker levels or nasopharyngeal/oropharyngeal severe acute respiratory syndrome coronavirus 2 viral load estimated by reverse transcriptase polymerase chain reaction cycle thresholds.
Conclusions: HIV infection status was associated with a higher admission rate; however, among hospitalized patients, PWH did not differ from HIV-uninfected controls by rate of mechanical ventilation or death/discharge to hospice.
Keywords: COVID-19; HIV-1; SARS-CoV-2.