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Open Forum Infect Dis . Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality

tetano

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2022 Aug 20;9(9):ofac427.
doi: 10.1093/ofid/ofac427. eCollection 2022 Sep.
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality


Joseph M Rocco[SUP] 1 [/SUP], Paola Laghetti[SUP] 2 3 [/SUP], Mariantonietta Di Stefano[SUP] 4 [/SUP], Irini Sereti[SUP] 1 [/SUP], Ana Ortega-Villa[SUP] 1 [/SUP], Jing Wang[SUP] 5 [/SUP], Adam Rupert[SUP] 6 [/SUP], Maria Chironna[SUP] 7 [/SUP], Lara Ye[SUP] 1 [/SUP], Xiangdong Liu[SUP] 1 [/SUP], Megan V Anderson[SUP] 1 [/SUP], Peter B Burbelo[SUP] 8 [/SUP], Jose Ramon Fiore[SUP] 4 [/SUP], Annalisa Saracino[SUP] 2 [/SUP], Andrea Lisco[SUP] 1 [/SUP]



Affiliations

Abstract

In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.

Keywords: COVID-19; endothelial damage; inflammation; metabolic biomarkers.
 
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