tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Sep 9;8(10)
fab440.
doi: 10.1093/ofid/ofab440. eCollection 2021 Oct.
Long COVID and Post-infective Fatigue Syndrome: A Review
Carolina X Sandler[SUP] 1 [/SUP], Vegard B B Wyller[SUP] 2 3 [/SUP], Rona Moss-Morris[SUP] 4 [/SUP], Dedra Buchwald[SUP] 5 [/SUP], Esther Crawley[SUP] 6 [/SUP], Jeannine Hautvast[SUP] 7 [/SUP], Ben Z Katz[SUP] 8 9 [/SUP], Hans Knoop[SUP] 10 [/SUP], Paul Little[SUP] 11 [/SUP], Renee Taylor[SUP] 12 [/SUP], Knut-Arne Wensaas[SUP] 13 [/SUP], Andrew R Lloyd[SUP] 1 [/SUP]
Affiliations
Abstract
Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
Keywords: COVID-19; assessment; cohorts; fatigue; post-viral.
. 2021 Sep 9;8(10)
fab440.doi: 10.1093/ofid/ofab440. eCollection 2021 Oct.
Long COVID and Post-infective Fatigue Syndrome: A Review
Carolina X Sandler[SUP] 1 [/SUP], Vegard B B Wyller[SUP] 2 3 [/SUP], Rona Moss-Morris[SUP] 4 [/SUP], Dedra Buchwald[SUP] 5 [/SUP], Esther Crawley[SUP] 6 [/SUP], Jeannine Hautvast[SUP] 7 [/SUP], Ben Z Katz[SUP] 8 9 [/SUP], Hans Knoop[SUP] 10 [/SUP], Paul Little[SUP] 11 [/SUP], Renee Taylor[SUP] 12 [/SUP], Knut-Arne Wensaas[SUP] 13 [/SUP], Andrew R Lloyd[SUP] 1 [/SUP]
Affiliations
- PMID: 34631916
- PMCID: PMC8496765
- DOI: 10.1093/ofid/ofab440
Abstract
Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
Keywords: COVID-19; assessment; cohorts; fatigue; post-viral.