tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 Nov 4;9(11)
fac596.
doi: 10.1093/ofid/ofac596. eCollection 2022 Nov.
Lung Abnormalities in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: An Analysis of Paired Computed Tomography Scans Before and After Infection
Katrine K Iversen[SUP] 1 [/SUP], Andreas Ronit[SUP] 1 [/SUP], Thomas S Kristensen[SUP] 2 [/SUP], Shoaib Afzal[SUP] 3 4 5 [/SUP], Jelena Jankovic[SUP] 2 [/SUP], Anna Kalhauge[SUP] 2 [/SUP], Magnus G Ahlström[SUP] 6 [/SUP], Børge G Nordestgaard[SUP] 3 4 5 [/SUP], Klaus F Kofoed[SUP] 2 [/SUP], Thomas Benfield[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Studies on the pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are impeded by limited access to pre-SARS-CoV-2 examinations.
Methods: We invited Copenhagen General Population Study participants with a confirmed SARS-CoV-2 polymerase chain reaction (PCR) test during the first and second coronavirus disease 2019 waves in Denmark for a repeat chest computed tomography (CT) scan. Paired CT scans were independently assessed for interstitial and noninterstitial abnormalities by 2 trained radiologists. A semiquantitative CT score (ranging from 0 to 20) was used to quantify the extent of interstitial abnormalities.
Results: Of 111 SARS-CoV-2-infected individuals, 102 (91.2%) experienced symptoms and 12 (11.2%) were hospitalized. Follow-up examination was performed at median of 5.4 (interquartile range, 4.1-7.8) months after a positive SARS-CoV-2 PCR test. Of 67 individuals with paired CT scans, ground glass opacities and reticulation were present in 31 (46.3%) individuals post-SARS-CoV-2 compared to 23 (34.1%) pre-SARS-CoV-2 (mean CT score, 3.0 vs 1.3; P = .011). Results were similar for nonhospitalized individuals. We did not detect development of bronchiectasis, emphysema, or nodules.
Conclusions: SARS-CoV-2 infection in predominantly nonhospitalized individuals with mild disease was associated with a small increase in only interstitial lung abnormalities.
Keywords: COVID-19; chest CT; lung abnormalities; lung function test; paired analysis.
. 2022 Nov 4;9(11)
fac596.doi: 10.1093/ofid/ofac596. eCollection 2022 Nov.
Lung Abnormalities in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: An Analysis of Paired Computed Tomography Scans Before and After Infection
Katrine K Iversen[SUP] 1 [/SUP], Andreas Ronit[SUP] 1 [/SUP], Thomas S Kristensen[SUP] 2 [/SUP], Shoaib Afzal[SUP] 3 4 5 [/SUP], Jelena Jankovic[SUP] 2 [/SUP], Anna Kalhauge[SUP] 2 [/SUP], Magnus G Ahlström[SUP] 6 [/SUP], Børge G Nordestgaard[SUP] 3 4 5 [/SUP], Klaus F Kofoed[SUP] 2 [/SUP], Thomas Benfield[SUP] 1 [/SUP]
Affiliations
- PMID: 36438618
- PMCID: PMC9685465
- DOI: 10.1093/ofid/ofac596
Abstract
Background: Studies on the pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are impeded by limited access to pre-SARS-CoV-2 examinations.
Methods: We invited Copenhagen General Population Study participants with a confirmed SARS-CoV-2 polymerase chain reaction (PCR) test during the first and second coronavirus disease 2019 waves in Denmark for a repeat chest computed tomography (CT) scan. Paired CT scans were independently assessed for interstitial and noninterstitial abnormalities by 2 trained radiologists. A semiquantitative CT score (ranging from 0 to 20) was used to quantify the extent of interstitial abnormalities.
Results: Of 111 SARS-CoV-2-infected individuals, 102 (91.2%) experienced symptoms and 12 (11.2%) were hospitalized. Follow-up examination was performed at median of 5.4 (interquartile range, 4.1-7.8) months after a positive SARS-CoV-2 PCR test. Of 67 individuals with paired CT scans, ground glass opacities and reticulation were present in 31 (46.3%) individuals post-SARS-CoV-2 compared to 23 (34.1%) pre-SARS-CoV-2 (mean CT score, 3.0 vs 1.3; P = .011). Results were similar for nonhospitalized individuals. We did not detect development of bronchiectasis, emphysema, or nodules.
Conclusions: SARS-CoV-2 infection in predominantly nonhospitalized individuals with mild disease was associated with a small increase in only interstitial lung abnormalities.
Keywords: COVID-19; chest CT; lung abnormalities; lung function test; paired analysis.