tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jun 4;8(7)
fab295.
doi: 10.1093/ofid/ofab295. eCollection 2021 Jul.
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
Ida Monrad[SUP] 1 2 [/SUP], Signe Risgaard Sahlertz[SUP] 3 [/SUP], Stine Sofie Frank Nielsen[SUP] 1 2 [/SUP], Louise Ørnskov Pedersen[SUP] 4 [/SUP], Mikkel Steen Petersen[SUP] 4 [/SUP], Carl Mathias Kobel[SUP] 5 [/SUP], Irene Harder Tarpgaard[SUP] 5 [/SUP], Merete Storgaard[SUP] 1 [/SUP], Klaus Leth Mortensen[SUP] 3 [/SUP], Mariane H Schleimann[SUP] 1 [/SUP], Martin Tolstrup[SUP] 1 2 [/SUP], Line K Vibholm[SUP] 1 [/SUP]
Affiliations
Abstract
We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
Keywords: CLL; SARS-CoV-2; persistent infection; viral evolution.
. 2021 Jun 4;8(7)
fab295.doi: 10.1093/ofid/ofab295. eCollection 2021 Jul.
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
Ida Monrad[SUP] 1 2 [/SUP], Signe Risgaard Sahlertz[SUP] 3 [/SUP], Stine Sofie Frank Nielsen[SUP] 1 2 [/SUP], Louise Ørnskov Pedersen[SUP] 4 [/SUP], Mikkel Steen Petersen[SUP] 4 [/SUP], Carl Mathias Kobel[SUP] 5 [/SUP], Irene Harder Tarpgaard[SUP] 5 [/SUP], Merete Storgaard[SUP] 1 [/SUP], Klaus Leth Mortensen[SUP] 3 [/SUP], Mariane H Schleimann[SUP] 1 [/SUP], Martin Tolstrup[SUP] 1 2 [/SUP], Line K Vibholm[SUP] 1 [/SUP]
Affiliations
- PMID: 34258320
- PMCID: PMC8244814
- DOI: 10.1093/ofid/ofab295
Abstract
We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
Keywords: CLL; SARS-CoV-2; persistent infection; viral evolution.